Results 11 to 20 of about 447,238 (255)

Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta

JCI Insight, 2023
Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a mechanoprotective role of YAP and TAZ in vascular smooth muscle cells (SMCs).
Marycarmen Arévalo Martínez, Olivia Ritsvall, Joakim Armstrong Bastrup, Selvi Celik, Gabriel Jakobsson, Fatima Daoud, Christopher Winqvist, Anders Aspberg, Catarina Rippe, Lars Maegdefessel, Alexandru Schiopu, Thomas A. Jepps, Johan Holmberg, Karl Swärd, Sebastian Albinsson   +14 more
doaj   +1 more source

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

JCI Insight, 2021
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by ...
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols   +15 more
doaj   +1 more source

Radiotherapy exposure directly damages the uterus and causes pregnancy loss

JCI Insight, 2023
Female cancer survivors are significantly more likely to experience infertility than the general population. It is well established that chemotherapy and radiotherapy can damage the ovary and compromise fertility, yet the ability of cancer treatments to ...
Meaghan J. Griffiths, Sarah A. Marshall, Fiona L. Cousins, Lauren R. Alesi, Jordan Higgins, Saranya Giridharan, Urooza C. Sarma, Ellen Menkhorst, Wei Zhou, Alison S. Care, Jacqueline F. Donoghue, Sarah J. Holdsworth-Carson, Peter A.W. Rogers, Evdokia Dimitriadis, Caroline E. Gargett, Sarah A. Robertson, Amy L. Winship, Karla J. Hutt   +17 more
doaj   +1 more source

Biology of Vascular Malformations of the Brain [PDF]

Stroke, 2009
Background and Purpose— This review discusses recent research on the genetic, molecular, cellular, and developmental mechanisms underlying the etiology of vascular malformations of the brain (VMBs), including cerebral cavernous malformation, sporadic brain arteriovenous malformation, and the ...
Leblanc GG, Golanov E, Awad IA, Young WL, Biology of Vascular Malformations of the Brain NINDS Workshop Collaborators:Awad I, Young WL, Berg M, Chopp M, Gale NW, Gunel M, Lo EH, Marchuk D, Rigamonti D, Tournier Lasserve E, Berg M, Blasig IE, Boudreau N, Chopp M, Gale NW, Ginsberg M, Jin K, Johnson GL, Kim H, Lawton MT, Letarte M, Li DY, Lo EH, Marchuk D, Mohr JP, Nishimura S, NOONAN, DOUGLAS, Pawlikowska L, Plate KH, Rigamonti D, Shenkar R, Tournier Lasserve E, Al Shahi Salman R, Ball KL, Clancy MS, Connolly SE Jr, Derry B, Faurobert E, Gault J, Golanov E, Hannegan L, Hashimoto T, Keep RF, Leblanc GG, Lee C, McCarty J, Morrison L, Ning M, Nunn MF, Oh SP, Plahn BK, Pratt CA, Pratt WB, Spatz M, Stapf C, Yang GY, Zhang J.   +60 more
openaire   +4 more sources

Redox Control of Vascular Biology. [PDF]

Oxid Med Cell Longev, 2019
Banerjee J, Ghose J, Sinha M, Sen S.
europepmc   +3 more sources

From vascular biology to vascular medicine

The EuroBiotech Journal, 2018
Cardiovascular disorders include various conditions characterized by morphological and functional defects of the heart and vascular system. Molecular biology techniques (in particular DNA sequencing) have recently offered new insights into the etiology ...
Paolacci Stefano, Rakhmanov Yeltay, Maltese Paolo Enrico, Bertelli Matteo   +3 more
doaj   +1 more source

Cilia proteins are biomarkers of altered flow in the vasculature

JCI Insight, 2022
Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC surface are lost, and more recent ...
Ankan Gupta, Karthikeyan Thirugnanam, Madhan Thamilarasan, Ashraf M. Mohieldin, Hadeel T. Zedan, Shubhangi Prabhudesai, Meghan R. Griffin, Andrew D. Spearman, Amy Pan, Sean P. Palecek, Huseyin C. Yalcin, Surya M. Nauli, Kevin R. Rarick, Rahima Zennadi, Ramani Ramchandran   +14 more
doaj   +1 more source

Neuropilin-1 deficiency in vascular smooth muscle cells is associated with hereditary hemorrhagic telangiectasia arteriovenous malformations

JCI Insight, 2022
Patients with hereditary hemorrhagic telangiectasia (HHT) have arteriovenous malformations (AVMs) with genetic mutations involving the activin-A receptor like type 1 (ACVRL1 or ALK1) and endoglin (ENG). Recent studies have shown that Neuropilin-1 (NRP-1)
Sreenivasulu Kilari, Ying Wang, Avishek Singh, Rondell P. Graham, Vivek Iyer, Scott M. Thompson, Michael S. Torbenson, Debabrata Mukhopadhyay, Sanjay Misra   +8 more
doaj   +1 more source

Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms

The Journal of Clinical Investigation, 2022
As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed flow (D-flow) in aneurysmal arteries, platelets are subjected to external forces.
Craig N. Morrell, Doran Mix, Anu Aggarwal, Rohan Bhandari, Matthew Godwin, Phillip Owens III, Sean P. Lyden, Adam Doyle, Krystin Krauel, Matthew T. Rondina, Amy Mohan, Charles J. Lowenstein, Sharon Shim, Shaun Stauffer, Vara Prasad Josyula, Sara K. Ture, David I. Yule, Larry E. Wagner III, John M. Ashton, Ayman Elbadawi, Scott J. Cameron   +20 more
doaj   +1 more source

Therapeutic MK2 inhibition blocks pathological vascular smooth muscle cell phenotype switch

JCI Insight, 2021
Vascular procedures, such as stenting, angioplasty, and bypass grafting, often fail due to intimal hyperplasia (IH), wherein contractile vascular smooth muscle cells (VSMCs) dedifferentiate to synthetic VSMCs, which are highly proliferative, migratory ...
J. William Tierney, Brian C. Evans, Joyce Cheung-Flynn, Bo Wang, Juan M. Colazo, Monica E. Polcz, Rebecca S. Cook, Colleen M. Brophy, Craig L. Duvall   +8 more
doaj   +1 more source