Results 191 to 200 of about 1,474,592 (383)

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

AKT-independent activation of p38 MAP kinase promotes vascular calcification

Redox Biology, 2018
Vascular calcification is prevalent in patients with atherosclerosis, and oxidative stress promotes pathogenesis of atherosclerosis. We have previously reported that activation of AKT by oxidative stress induces vascular calcification.
Youfeng Yang, Yong Sun, Jianye Chen, Wayne E. Bradley, Louis J. Dell’Italia, Hui Wu, Yabing Chen   +6 more
doaj  

Teriparatide (Human Parathyroid Hormone (1–34)) Inhibits Osteogenic Vascular Calcification in Diabetic Low Density Lipoprotein Receptor-deficient Mice [PDF]

, 2003
Jian-Su Shao, Su‐Li Cheng, Nichole Charlton-Kachigian, Arleen P. Loewy, Dwight A. Towler   +4 more
openalex   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Intracardiac Calcification - An Interesting Chest X-ray Report. [PDF]

, 2013
We report a case of chest X-ray finding of mitral annular calcification. Mitral annular calcification is a degenerative process involving the fibrous annulus of the mitral valve.
Anupama, N, Basavaraj, S, Harsha, DS, Pradeepa, N, Sharma, VM, Simon, RA   +5 more
core  

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, EarlyView.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Role of Molecular Regulation in Vascular Calcification

, 1996
Farhad Parhami, Kristina Bostr ouml m, Karol E. Watson, Linda L. Demer   +3 more
openalex   +2 more sources

Slowing the Progression of Vascular Calcification in Hemodialysis [PDF]

, 2003
Glenn M. Chertow
openalex   +1 more source

Immunosuppressive Formulations for Immunological Defense against Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A novel subcutaneous formulation combining alpha‐ketoglutarate, glycolysis inhibitor PFK15, and a myelin peptide reduces inflammation in a mouse TBI model. This formulation promotes regulatory immune cells, enhances autophagy, and improves motor function, suggesting its potential as a prophylactic immunosuppressive therapy to mitigate TBI‐induced ...
Kelly Lintecum, Abhirami Thumsi, Kara Dunn, Lindsey Druschel, Sierra Chimene, David Flores Prieto, Amberlyn Simmons, Shivani Mantri, Arezoo Esrafili, Srivatsan J. Swaminathan, Mytreyi Trivedi, Shreya Anandan, Crystal Willingham, Alondra Davila, Sahil Inamdar, Joslyn L. Mangal, Abhirami P. Suresh, Niveda M. Kasthuri, Madan Mohan Chandra Sekhar Jaggarapu, Nicole Appel, Taravat Khodaei, Nathan D. Ng, Alison Sundem, Sanmoy Pathak, George Bjorklund, Jason Newbern, Jeffrey Capadona, Sarah E. Stabenfeldt, Abhinav P. Acharya   +28 more
wiley   +1 more source