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Vascular calcification

Current Opinion in Nephrology and Hypertension, 1999
Vascular calcification is an active and modifiable process involved in many disease entities, including atherosclerosis, cardiac valve disease and calcific uremic arteriolopathy. It occurs with distinct characteristics at different sites in the vessel wall.
R C, Christian, L A, Fitzpatrick
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Inflammation and Vascular Calcification

Blood Purification, 2005
Both vascular calcification and inflammation are common in patients with chronic kidney disease (CKD). In patients on dialysis, there is increased coronary artery and peripheral artery calcification compared to the general population. Both intimal (atherosclerotic) and medial calcification in CKD patients are associated with increased morbidity and ...
Sharon M, Moe, Neal X, Chen
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Imaging for Vascular Calcification

Seminars in Dialysis, 2017
AbstractChronic decline in renal function is accompanied by deterioration of bone structure and function and progressive calcification of the vascular system. Both disease states have been linked with increased morbidity and mortality in chronic kidney disease.
Paolo, Raggi, W Charles, O'Neill
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Vascular calcification in dermatopathology

The American Journal of Dermatopathology, 1979
Calcification in cutaneous blood vessels is an uncommon finding in biopsies submitted for dermatopathological examination. Of 14 biopsy specimens showing the phenomenon that was studied by us, the greater number was from women who had a combination of severe diabetes, hypertension, and atherosclerosis.
S, Kossard, R K, Winkelmann
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Vascular Calcification [PDF]

open access: yesCirculation Research, 2006
Once thought to result from passive precipitation of calcium and phosphate, it now appears that vascular calcification is a consequence of tightly regulated processes that culminate in organized extracellular matrix deposition by osteoblast-like cells. These cells may be derived from stem cells (circulating or within the vessel wall) or differentiation
Jane A Leopold, Joseph Loscalzo
exaly   +3 more sources

The biology of vascular calcification

2020
Vascular calcification (VC), characterized by different mineral deposits (i.e., carbonate apatite, whitlockite and hydroxyapatite) accumulating in blood vessels and valves, represents a relevant pathological process for the aging population and a life-threatening complication in acquired and in genetic diseases.
Quaglino D., Boraldi F., Lofaro F. D.
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Vascular calcification

Current Opinion in Nephrology & Hypertension, 2005
Accumulating evidence suggests that the high cardiovascular mortality observed in patients with end-stage renal disease is due in part to the deleterious effects of vascular calcification that develops over time on dialysis. This review focuses on recent cell biological and animal studies that have shed light on the mechanisms and regulators of ...
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Warfarin and Vascular Calcification

The American Journal of Medicine, 2016
The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP).
Timothy J, Poterucha   +1 more
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Mechanisms of Vascular Calcification

Advances in Chronic Kidney Disease, 2007
Vascular calcification is highly prevalent and correlated with high rates of cardiovascular mortality in chronic kidney disease patients. Recent evidence suggests that mineral, hormonal, and metabolic imbalances that promote phenotype change in vascular cells as well as deficiencies in specific mineralization inhibitory pathways may be important ...
Mohga, El-Abbadi, Cecilia M, Giachelli
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Uremic Vascular Calcification

Journal of Investigative Medicine, 2006
Recent evidence suggests that uremic vascular calcification is an active, cell-mediated process resembling osteogenesis in bone rather than passive precipitation. We identified increased expression of bone-associated proteins (osteopontin, bone sialoprotein, alkaline phosphatase, type I ...
Neal X, Chen, Sharon M, Moe
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