Results 31 to 40 of about 621,125 (228)
A genome-wide association meta-analysis of all-cause and vascular dementia. [PDF]
IntroductionDementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD.MethodsWe conducted a GWAS of all-cause ...
Mega Vascular Cognitive Impairment and Dementia (MEGAVCID) conso
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Alzheimer and vascular brain diseases: Focal and diffuse subforms. [PDF]
, 2015 Alois Alzheimer is best known for his description of the pre-senile neurodegenerative disease named after him. However, his previous interest in vascular brain diseases, underlying cognitive and behavioral changes, was very strong. Besides describing the
Engelhardt, Eliasz, Grinberg, Lea T
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Frequency and Underlying Pathology of Pure Vascular Cognitive Impairment.
JAMA Neurology, 2022 Importance It is not clear how common pure vascular cognitive impairment (VCI) is in the absence of Alzheimer disease (AD) and/or other neurodegenerative pathologies. Objective To identify participants without AD and other neurodegenerative pathologies
S. Oveisgharan +7 more
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Interactive effects of vascular risk burden and advanced age on cerebral blood flow. [PDF]
, 2014 Vascular risk factors and cerebral blood flow (CBF) reduction have been linked to increased risk of cognitive impairment and Alzheimer's disease (AD); however the possible moderating effects of age and vascular risk burden on CBF in late life remain ...
Bangen, Katherine J +10 more
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Frontiers in Aging Neuroscience, 2022 Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) leads to
Mosi Li +13 more
semanticscholar +1 more source
Redox Biology, 2019 Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling (NVC) has an essential role in maintenance of healthy cognitive function.
Stefano Tarantini +14 more
doaj +1 more source
Perfil neuropsicológico em pacientes com lesões vasculares subcorticais [PDF]
, 2012 Vascular cognitive impairment (VCI) is characterized by cognitive compromise predominantly of executive dysfunction. OBJECTIVES: To assess cognitive functions in VCI, focusing on executive functions, to observe functional losses in relation to activities
Andrade, Silviane Pinheiro Campos de +3 more
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The PASTIS trial: Testing tadalafil for possible use in vascular cognitive impairment
Alzheimer's & Dementia, 2022 There are few randomized clinical trials in vascular cognitive impairment (VCI). This trial tested the hypothesis that the PDE5 inhibitor tadalafil, a widely used vasodilator, increases cerebral blood flow (CBF) in older people with symptomatic small ...
M. Pauls +23 more
semanticscholar +1 more source
Advances in Vascular Cognitive Impairment [PDF]
Stroke, 2013 Vascular cognitive impairment (VCI) has continued to evolve over the past year. Much of the data has been confirmatory with further work on risk factors, silent strokes, leukoaraiosis and lesion volume and location. The importance of the interaction between cerebrovascular disease and other causes of cognitive impairment, most importantly Alzheimer ...
Gorelick, Philip B, PANTONI, LEONARDO
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Vascular cognitive impairment: issues of diagnosis and treatment
Неврология, нейропсихиатрия, психосоматика, 2023 Vascular brain diseases are one of the leading causes of death and disability in developed countries. Along with acute disturbance of cerebral circulation, chronic cerebrovascular diseases, which manifest as vascular cognitive impairment (VCI), are of ...
A. B. Lokshina +2 more
doaj +1 more source