Results 51 to 60 of about 2,053,431 (310)

Notch Signaling in Vascular Development [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2003
Notch signaling is an extremely conserved and widely used mechanism regulating cell fate in metazoans. Interaction of Notch receptors (Notch) with their ligands (Delta-like or Jagged) leads to cleavage of the Notch intracellular domain (NICD) that migrates into the nucleus. In the nucleus, NICD associates with a transcription factor, RBP-Jk.
Tatsuya, Iso, Yasuo, Hamamori, Larry, Kedes   +2 more
openaire   +2 more sources

Specialized mouse embryonic stem cells for studying vascular development. [PDF]

, 2014
Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B, Fan, Yuhong, Glaser, Drew E, Hatano, Rachel, McCloskey, Kara E, Medrzycki, Magdalena   +5 more
core   +1 more source

Motor neuron-derived Thsd7a is essential for zebrafish vascular development via the Notch-dll4 signaling pathway. [PDF]

, 2016
BackgroundDevelopment of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions.
Chuang, Yung-Jen, Huang, Yi-Ching, Jao, Li-En, Jiang, Jie-Peng, Lai, Zih-Yin, Lin, Min-Hsuan, Liu, Lawrence Yu-Min   +6 more
core   +2 more sources

Six-year outcomes of a phase II study of human-tissue engineered blood vessels for peripheral arterial bypass

JVS - Vascular Science, 2023
Objective: The human acellular vessel (HAV) was evaluated for surgical bypass in a phase II study. The primary results at 24 months after implantation have been reported, and the patients will be evaluated for ≤10 years.
Piotr Gutowski, MD, PhD, Malgorzata Guziewicz, MD, PhD, Marek Ilzecki, MD, PhD, Arkadiusz Kazimierczak, MD, PhD, Jeffrey H. Lawson, MD, PhD, Heather L. Prichard, PhD, Stanislaw Przywara, MD, PhD, Rabih Samad, MD, PhD, William Tente, MS, Jakub Turek, MD, Wojcieh Witkiewicz, MD, PhD, Norbert Zapotoczny, MD, Tomaz Zubilewicz, MD, PhD, Laura E. Niklason, MD, PhD   +13 more
doaj   +1 more source

Mechanotransduction in embryonic vascular development [PDF]

Biomechanics and Modeling in Mechanobiology, 2012
A plethora of biochemical signals provides spatial and temporal cues that carefully orchestrate the complex process of vertebrate embryonic development. The embryonic vasculature develops not only in the context of these biochemical cues, but also in the context of the biomechanical forces imparted by blood flow.
Beth L, Roman, Kerem, Pekkan
openaire   +2 more sources

Mechanisms of vascular smooth muscle contraction and the basis for pharmacologic treatment of smooth muscle disorders [PDF]

, 2016
The smooth muscle cell directly drives the contraction of the vascular wall and hence regulates the size of the blood vessel lumen. We review here the current understanding of the molecular mechanisms by which agonists, therapeutics, and diseases ...
Aggarwal, M., Brozovich, F. V., Degen, C. V., Gao, Yuan Z., Morgan, K. G., Nicholson, C. J.   +5 more
core   +1 more source

Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1 [PDF]

, 2015
Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of ...
Palmer, Timothy P., Yarwood, Stephen J.
core   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Vascular Development in the Zebrafish [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
The zebrafish has emerged as an excellent vertebrate model system for studying blood and lymphatic vascular development. The small size, external and rapid development, and optical transparency of zebrafish embryos are some of the advantages the zebrafish model system offers.
Aniket V, Gore, Kathryn, Monzo, Young R, Cha, Weijun, Pan, Brant M, Weinstein   +4 more
openaire   +2 more sources

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

, 2011
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff, Abtahian, Alice Y. Pollitt, Aparicio-Vergara, Bertozzi, Bohmer, Brenda A. Finney, Caetano Reis e Sousa, Carramolino, Caton, Cecile Bénézech, Chagraoui, Cheng, Christou, Clausen, Colonna, Craig E. Hughes, Cueni, de Boer, Diego Mourao-Sa, Edina Schweighoffer, Francesca Barone, Gerard B. Nash, Gustafsson, Hodivala-Dilke, Hughes, Hughes, Humphreys, Ichise, Kate L. Lowe, Kaufmann, Kerrigan, Leyre Navarro-Núñez, Makinen, Martin-Villar, May, Mocsai, Mourao-Sa, Navarro, Navarro, Nicholas Smithers, Nieswandt, Pardridge, Ramirez, Saijo, Schacht, Sebzda, Spalton, Stacey A. Langan, Steve P. Watson, Steve Sheardown, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Tammela, Tang, Tiedt, Tober, Turner, Uhrin, Victor L. J. Tybulewicz, Warburton, Watson, Williams, Xie, Xu   +66 more
core   +2 more sources