Results 81 to 90 of about 2,053,431 (310)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Sex differences in machine learning computed tomography-derived fractional flow reserve

Scientific Reports, 2022
Coronary computed tomography angiography (CCTA) derived machine learning fractional flow reserve (ML-FFRCT) can assess the hemodynamic significance of coronary artery stenoses.
Mahmoud Al Rifai, Ahmed Ibrahim Ahmed, Yushui Han, Jean Michel Saad, Talal Alnabelsi, Faisal Nabi, Su Min Chang, Myra Cocker, Chris Schwemmer, Juan C. Ramirez-Giraldo, William A. Zoghbi, John J. Mahmarian, Mouaz H. Al-Mallah   +12 more
doaj   +1 more source

Angiopoietins differentially influence in vitro angiogenesis by endothelial cells of different origin [PDF]

, 2011
Angiopoietins are important growth factors for vascular development and quiescence. They are promising targets for pro-or anti-angiogenic therapies in diverse pathologies, but the mechanisms of the ANGPT/TIE2 system are complex and not well understood ...
Bahramsoltani, Mahtab, Cornillie, Pieter, De Spiegelaere, Ward, Plendl, Johanna, Van Den Broeck, Wim   +4 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Impact of Infection in Pregnancy on Placental Vascular Development and Adverse Birth Outcomes

Frontiers in Microbiology, 2019
Healthy fetal development is dependent on nutrient and oxygen transfer via the placenta. Optimal growth and function of placental vasculature is therefore essential to support in utero development.
Andrea M. Weckman, Michelle Ngai, Julie Wright, Chloe R. McDonald, Kevin C. Kain, Kevin C. Kain, Kevin C. Kain   +6 more
doaj   +1 more source

Evaluation of the zucker diabetic fatty (ZDF) rat as a model for human disease based on urinary peptidomic profiles [PDF]

, 2012
Representative animal models for diabetes-associated vascular complications are extremely relevant in assessing potential therapeutic drugs. While several rodent models for type 2 diabetes (T2D) are available, their relevance in recapitulating renal and ...
Antonia Vlahou, Ariela Benigni, B Jonsson, Bernd Mayer, C Delles, C Weyer, C Zoja, Carlamaria Zoja, CD Wenger, CL Oltman, CS Fox, D Theodorescu, Ferdinand H. Bahlmann, H Mischak, H Mischak, Harald Mischak, J Drube, J Toblli, JO Deguchi, Joachim Jankowski, Julie Klein, Justyna Siwy, K Voros, Karin Jandeleit-Dahm, M Hashemi, M Haubitz, N Ahmed, N Verzijl, ND Rawlings, P Zurbig, Paul Perco, PJ Talmud, PR Cutillas, R Rouse, Robert Stevens, S Andersen, S Wild, SA Varghese, Sophia Kossida, T Nakagawa, TW Kurtz, Wiliam Mullen, Y Benjamini, Y Igarashi   +43 more
core   +3 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Changes in microvascular perfusion of heart and skeletal muscle in sheep around the time of birth

Experimental Physiology, 2023
Microvascular perfusion of striated muscle is an important determinant of health throughout life. Birth is a transition with profound effects on the growth and function of striated muscle, but the regulation of microvascular perfusion around this ...
Matthew W. Hagen, Samantha Louey, Sarah M. Alaniz, Todd Belcik, Matthew M. Muller, Laura Brown, Jonathan R. Lindner, Sonnet S. Jonker   +7 more
doaj   +1 more source