Results 61 to 70 of about 618,225 (305)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Vascular Endothelial Growth Factor gene +405G>C polymorphism in the Cuban population

Revista Habanera de Ciencias Médicas, 2020
Introduction: The vascular endothelial growth factor (VEGF) is a protein involved in the proliferation and cell migration of the vascular endothelium. In its gene, +405G>C Polymorphism has been reported. There are no population genetic reports of this
Francisco Sotomayor Lugo, Julia Azanza Ricardo, Ixchel López Reyes, Vivian Veiga Loyola, Yohandra Crespo Ferrá   +4 more
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination

Journal of Extracellular Vesicles, 2020
Early dissemination is a unique characteristic and a detrimental process of pancreatic ductal adenocarcinoma (PDAC); however, the underlying mechanism remains largely unknown.
Chu-An Wang, I-Heng Chang, Pei-Chi Hou, Yu-Jing Tai, Wan-Ning Li, Pei-Ling Hsu, Shang-Rung Wu, Wen-Tai Chiu, Chien-Feng Li, Yan-Shen Shan, Shaw-Jenq Tsai   +10 more
doaj   +1 more source

The complex TIE between macrophages and angiogenesis [PDF]

, 2020
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration.
Anghelina M., Avraham‐Davidi I., Baer C., Bailey A. S., Barnett F. H., Bonnardel J., Chakarov S., Chen L., Coffelt S. B., Corliss B. A., Cursiefen C., Daly C., Davies L. C., Davies L. C., De Palma M., De Palma M., De Palma M., De Palma M., De Palma M., De Spiegelaere W., DeFalco T., Deshmane S. L., Detry B., Dimova I., Dimova I., Eklund L., Elamaa H., Eubank T. D., Fantin A., Ferrari G., Fukuhara S., Ganta V. C., Ganta V. C., García S., Gerri C., Grunewald M., Guo L., Gurevich D. B., Hamm A., Hazan A. D., He H., Hoeffel G., Itoh M., Jetten N., Kim M., Kochhan E., Korhonen E. A., Korpelainen E. I., Krishnasamy K., Kumar A. H., Leibovich S. J., Lim H. Y., Liu C., Lucas T., Master Z., Metharom P., Michaeli S., Moldovan N. I., Moore E. M., Mueller S. B., Murdoch C., Murray P. J., Patel A. S., Polverini P. J., Potente M., Pucci F., Saharinen P., Saharinen P., Schif‐Zuck S., Schmeisser A., Seaman S. A., Seok S. H., Spiller K. L., Venneri M. A., Vestweber D., Webster N. L., West M. E. D., Willenborg S., Yamamoto S., Zajac E., Zenker D., Zhang W.   +81 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Tumor angiogenesis after heated lipiodol infusion via the hepatic artery in a rabbit model of VX2 liver cancer. [PDF]

PLoS ONE, 2013
OBJECTIVES: This study aimed to observe the changes in tumor angiogenesis after heated lipiodol (60°C) infusion via the hepatic artery in a rabbit model of VX2 liver cancer.
Wei Cao, Xiang Xu, Juliang Zhang, Yunyou Duan   +3 more
doaj   +1 more source

Expression of vascular endothelial growth factor-C and vascular endothelial growth factor receptor-3 in esophageal squamous cell carcinoma

Oncology Letters, 2014
Lymph node metastasis is one of the most important prognostic factors in esophageal squamous cell carcinoma (ESCC). Vascular endothelial growth factor (VEGF)-C and its receptor, VEGF receptor-3 (VEGFR-3), are key in the process of lymphangiogenesis.
OMOTO, ITARU, MATSUMOTO, MASATAKA, OKUMURA, HIROSHI, UCHIKADO, YASUTO, SETOYAMA, TETSURO, KITA, YOSHIAKI, OWAKI, TETSUHIRO, KIJIMA, YUKO, SHINCHI, HIROYUKI, ISHIGAMI, SUMIYA, UENO, SHINICHI, NATSUGOE, SHOJI   +11 more
openaire   +3 more sources

VEGF-C/VEGFR-3 and PDGF-B/PDGFR-b pathways in embryonic lymphangiogenesis [PDF]

, 2008
The circulatory system comprises the blood vascular system and the lymphatic vascular system. These two systems function in parallel. Blood vessels form a closed system that delivers oxygen and nutrients to the tissues and removes waste products from the
Haiko, Paula
core  

Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices [PDF]

, 2017
Vascular network engineering is essential for nutrient delivery to tissue-engineered constructs and, consequently, their survival. In addition, the functionality of tissues also depends on tissue drainage and immune cell accessibility, which are the main
Hasenberg, Tobias, Holnthoner, Wolfgang, Knezevic, Lea, Marx, Uwe, Mühleder, Severin, Priglinger, Eleni, Redl, Heinz, Schaupper, Mira, Schimek, Katharina   +8 more
core   +1 more source