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Vascular Endothelial Growth Factor and Angiogenesis
Pharmacological Reviews, 2004Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various ischemic and inflammatory diseases. A rich variety of pro- and antiangiogenic molecules have already been discovered. Vascular endothelial growth factor (VEGF) is an interesting inducer of angiogenesis and lymphangiogenesis, because it is a highly specific mitogen for
Ann Hoeben +5 more
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Vascular endothelial growth factor
Journal of Neuro-Oncology, 1997Vascular endothelial growth factor (VEGF) is a hypoxia-inducible angiogenesis and vascular permeability factor which is expressed in high amounts in perinecrotic palisading cells in human glioblastomas. In vitro VEGF gene expression is enhanced approximately ten times by hypoxia.
Plate, Karlheinz, Warnke, Peter C.
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Vascular Endothelial Growth Factor
Ophthalmology, 2007Vascular endothelial growth factor (VEGF) signalling is a key stimulant of tumour neovascular growth, survival and capillary permeability, which are critical to solid tumour progression. The intracellular signalling responses that induce an angiogenic phenotype are dependent upon VEGF binding to specific transmembrane receptors on the endothelium and ...
Juliane M. Jürgensmeier +1 more
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Intravitreal vascular endothelial growth factor [PDF]
Graefe's Archive for Clinical and Experimental Ophthalmology, 2014 To evaluate whether a specific pre-analytical stabilization regimen is needed for naïve vitreous taps to detect true values of intrinsic VEGF levels.Fourteen consecutive patients with different vitreomacular pathologies without blood-retina-barrier breakdown were scheduled for standard 23-gauge three-port pars plana vitrectomy, and naïve vitreous taps ...
Thomas W. Stief +6 more
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Vascular endothelial growth factor is a secreted angiogenic mitogen.
Science, 1989Vascular endothelial growth factor (VEGF) was purified from media conditioned by bovine pituitary folliculostellate cells (FC). VEGF is a heparin-binding growth factor specific for vascular endothelial cells that is able to induce angiogenesis in vivo ...
D. Leung +4 more
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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis.
Journal of Clinical Oncology, 2005New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has been of keen interest in the field of cancer research.
D. Hicklin, L. Ellis
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Vascular Endothelial Growth Factor and Vascular Homeostasis
Proceedings of the American Thoracic Society, 2011Vascular endothelial growth factor (VEGF) is the angiogenic factor promoting and orchestrating most, if not all, processes of neovascularization taking place in the embryo and the adult. VEGF is also required to sustain newly formed vessels and plays additional multiple roles in the maintenance and function of certain mature vascular beds ...
Alon Lazarus, Eli Keshet
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Vascular endothelial growth factor in the lung
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2006Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor that has a broad impact on endothelial cell function. The lung tissue is very rich in this protein; many different lung cells produce VEGF and also respond to VEGF.
Rubin M. Tuder +2 more
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