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1999
Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the ...
Peter Carmeliet, Desire Collen
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Distinct cellular processes mediate blood-vessel formation during embryogenesis (Beck and D’Amore 1997; Carmeliet and Collen 1998a; Folkman and D’Amore 1996; Noden 1989; Risau 1997; Wilting and Christ 1996) (Fig. 1). Initially, mesodermal cells differentiate in situ into early haemangioblasts and form cellular aggregates (blood islands), in which the ...
Peter Carmeliet, Desire Collen
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Vascular endothelial growth factor
The International Journal of Biochemistry & Cell Biology, 1998Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis in development, in cancer and in other important diseases. VEGF regulates multiple endothelial cell functions including mitogenesis, permeability, vascular tone, and the production of vasoactive molecules.
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Trends in Cardiovascular Medicine, 1998
The endothelial cells lining all vessels of the circulatory system have been recognized as key players in a variety of physiological and pathological settings. They act as regulators of vascular tone via the inducible nitric oxide system and in angiogenesis, the formation of blood vessels de novo. Aberrant regulation of endothelial cells contributes to
Berndt Enholm +3 more
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The endothelial cells lining all vessels of the circulatory system have been recognized as key players in a variety of physiological and pathological settings. They act as regulators of vascular tone via the inducible nitric oxide system and in angiogenesis, the formation of blood vessels de novo. Aberrant regulation of endothelial cells contributes to
Berndt Enholm +3 more
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Frontiers in Bioscience, 2007
Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo Cai, Xiaoyuan Chen
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Angiogenesis is a critical process in both physiological development and many pathological processes. Vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) signaling pathway plays a pivotal role in regulating angiogenesis. Many therapeutic agents targeting VEGF and VEGFR are currently in preclinical and clinical development.
Weibo Cai, Xiaoyuan Chen
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Current Vascular Pharmacology, 2017
Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception.
K. Siveen +8 more
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Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception.
K. Siveen +8 more
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Vascular Endothelial Growth Factor and Microvascular Permeability
Microcirculation, 1999ABSTRACTVascular Endothelial Growth Factors (VEGFs) are endogenously produced vascular cytokines which result in angiogenesis, vasodilatation, and increased microvascular permeabilityin vivo. They are endothelial specific and result in mitosis, migration, stress fiber formation and increased permeability of endothelial cells in culture.
Bates, DO, Lodwick, D, Williams, B
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Vascular Endothelial Growth Factor in Cervical Carcinoma
Obstetrics & Gynecology, 1999To quantitate vascular endothelial growth factor of cervical carcinoma and elucidate its clinical correlation.Intratumoral protein levels of vascular endothelial growth factor were measured in 104 cervical cancer patients and in 30 cervical tissue specimens of benign gynecologic diseases as controls. The concentrations were correlated with clinical and
Fon-Jou Hsieh +5 more
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Vascular Endothelial Growth Factor and its Receptors
Retina, 1994Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells and an angiogenic factor that is structurally related to platelet derived growth factor (PDGF). It is also known as the vascular permeability factor (VPF) because it efficiently potentiates the permeabilization of blood vessels. Five types of VEGF mRNA
Gera Neufeld +4 more
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Vascular Endothelial Growth Factor
2003The striking structural and anatomical parallels between the vasculature and the nervous system is reflected by the fact that these two organ systems appear to use related mechanisms during their development. Thus, it is not surprising that an increasing number of vascular biologists and researchers in the neuroscience field are fascinated by molecules
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Vascular endothelial cadherin and vascular endothelial growth factor in periodontitis and smoking
Oral Diseases, 2014ObjectiveThis study investigated the vascularization in periodontal disease process via revealing: (i) vascular endothelial cadherin (VE‐cadherin) and vascular endothelial growth factor (VEGF) productions in periodontitis and (ii) the impact of smoking on this phenomenon.Materials and MethodsFifteen smokers and 15 non‐smokers with/without periodontitis
Sakallioglu, E. E. +4 more
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