Results 121 to 130 of about 650,658 (370)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Role of Pentacyclic Triterpenoids in Chemoprevention and Anticancer Treatment: An Overview on Targets and Underling Mechanisms

Journal of Pharmacopuncture, 2019
DNA: Deoxyribonucleic acid, BRCA1: Breast cancer gene 1, BRCA2: Breast cancer gene 2,WHO: World Health Organization, Nrf2: Nuclear factor erythroid 2 [NF-E2]-related factor 2 , NF-κB: Nuclear factor kappa-light-chain-enhancer of activated B cells, MDR ...
Mahavir H. Ghante, Prasad G. Jamkhande
doaj   +1 more source

Stochastic models of the binding kinetics of VEGF-A to VEGFR1 and VEGFR2 in endothelial cells [PDF]

arXiv, 2016
Vascular endothelial growth factor receptors (VEGFRs) are receptor tyrosine kinases (RTKs) that regulate proliferation, migration, angiogenesis and vascular permeability of endothelial cells. VEGFR1 and VEGFR2 bind vascular endothelial growth factors (VEGFs), inducing receptor dimerisation and activation, characterised by phosphorylation of tyrosine ...
arxiv  

Molecular targeted therapies for breast cancer treatment [PDF]

Targeting the oestrogen receptor, HER2 (human epidermal growth factor receptor 2) and vascular endothelial growth factor has markedly improved breast cancer therapy.
A Eniu, A Lin, A Reid, AF Leary, AR Tan, AU Buzdar, B Brandt, B Overmoyer, B Ramaswamy, BM Ryan, Burkhard Brandt, C Catania, CE Geyer, CH Yang, Claus M Schlotter, D Slamon, D Slamon, DB Solit, EH Romond, F Cardoso, F Liu, F Schuetz, FJ Esteva, G Arpino, G Sabnis, G Sledge, G Tsakonas, GE Konecny, GN Hortobagyi, H Burstein, H Donninger, H Hernandez-Vargas, H Joensuu, H Kim, H Nakshatri, H Tennis, H Xing, Heike Allgayer, HS Rugo, HS Rugo, J Domingo-Domenech, J Gligorov, J Marshall, JA Bernstein, JC Feldner, JC Reed, JE Kendrick, K Miller, K Wu, KD Miller, KJ Kim, KM Ahmed, KS Garman, LH Saal, LH Wang, LM Witters, M Cristofanilli, M Cristofanilli, M Ghobriall, M Guix, M Pegram, M Pegram, MA Cobleigh, MA Troester, MJ Piccart-Gebhart, NG Schaefer, NJ Bundred, NM Appels, NR Wall, P Marchetti, P Schmid, R Nahta, R Nahta, RH Engel, S Massarweh, S Modi, S Pruthi, S Wittmann, SB Bull, SB Wedam, SM Russo, U Vogt, Ulf Vogt, Y Li, Y Luo, Y Zafar, Y Zhou, YH Wang, YJ Choi, Z Zhu   +89 more
core   +2 more sources

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Apatinib for molecular targeted therapy in tumor

Drug Design, Development and Therapy, 2015
Haijun Zhang Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China Abstract: As tumor angiogenesis is one of the hallmarks of cancer, the inhibition of vascular endothelial growth ...
Zhang H
doaj  

Integrative modeling of sprout formation in angiogenesis: coupling the VEGFA-Notch signaling in a dynamic stalk-tip cell selection [PDF]

arXiv, 2016
During angiogenesis, new blood vessels headed by a migrating endothelial tip cell sprout from pre-existing ones. This process is known to be regulated by two signaling pathways concurrently, vascular endothelial growth factor A (VEGFA) and Notch-Delta. Extracellular VEGFA activates the intracellular Notch-Delta pathway in nearby endothelial cells which
arxiv  

Activation of Vascular Endothelial Growth Factor Receptor 2 in a Cellular Model of Loricrin Keratoderma [PDF]

Journal of Biological Chemistry, 2010
Loricrin is a major constituent of the epidermal cornified cell envelope. Recently, heterozygous loricrin gene mutations have been identified in two dominantly inherited skin diseases, Vohwinkel syndrome with ichthyosis and progressive symmetric erythrokeratoderma, collectively termed loricrin keratoderma.
Yasuo Kubota, Kozo Nakai, Kozo Yoneda, Junsuke Igarashi, Toshio Demitsu, Hiroaki Kosaka, Wataru Ogawa, Tetsuya Moriue   +7 more
openaire   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source