Results 131 to 140 of about 650,658 (370)

Pazopanib for the treatment of soft-tissue sarcoma

Clinical Pharmacology: Advances and Applications, 2012
Pierre Heudel,1 Philippe Cassier,1 Olfa Derbel,1 Armelle Dufresne,1 Pierre Meeus,2 Philippe Thiesse,3 Dominique Ranchère-Vince,4 Jean Yves Blay,1 Isabelle Ray-Coquard1,51Department of Medical Oncology, 2Department of Surgical Oncology ...
Heudel P, Cassier P, Derbel O, Dufresne A, Meeus P, Thiesse P, Ranchère-Vince D, Blay JY, Ray-Coquard I   +8 more
doaj  

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

Ubiquitination of basal VEGFR2 regulates signal transduction and endothelial function

Biology Open, 2017
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined.
Gina A. Smith, Gareth W. Fearnley, Izma Abdul-Zani, Stephen B. Wheatcroft, Darren C. Tomlinson, Michael A. Harrison, Sreenivasan Ponnambalam   +6 more
doaj   +1 more source

3D CA model of tumor-induced angiogenesis [PDF]

arXiv, 2020
Tumor-induced angiogenesis is the formation of new sprouts from preexisting nearby parent blood vessels. Computationally, tumor-induced angiogenesis can be modeled using cellular automata (CA), partial differential equations, etc. In this present study, a realistic physiological approach has been made to model the process of angiogenesis by using 3D CA
arxiv  

PAKing up to the endothelium [PDF]

, 2009
Angiogenesis recapitulates the growth of blood vessels that progressively expand and remodel into a highly organized and stereotyped vascular network. During adulthood, endothelial cells that formed the vascular wall retain their plasticity and can be engaged in neo-vascularization in response to physiological stimuli, such as hypoxia, wound healing ...
arxiv   +1 more source

Gremlin is a novel agonist of the major pro-angiogenic receptor VEGFR2 [PDF]

, 2010
The bone morphogenic protein antagonist gremlin is expressed during embryonic development and under different pathologic conditions, including cancer. Gremlin is a proangiogenic protein belonging to the cystine-knot superfamily that includes transforming
Ballmer-Hofer K, Leali D, Mitola S, Moroni E, Presta M., Ravelli C, Salvi V, Zammataro L   +7 more
core   +1 more source

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

Aging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Development of a Computationally Optimized Model of Cancer-induced Angiogenesis through Specialized Cellular Mechanics [PDF]

arXiv, 2016
Angiogenesis, the development of new vasculature, is a critical process in the growth of new tumors. Driven by a goal to understand this aspect of cancer proliferation, I develop a discrete computationally optimized mathematical model of angiogenesis that specializes in intercellular interactions.
arxiv  

Deterministic and stochastic aspects of VEGF-A production and the cooperative behavior of tumoral cell colony [PDF]

, 2010
A model is proposed to study the process of hypoxia-induced angiogenesis in cancer cells. The model accounts for the role played by the vascular endothelial growth factor (VEGF)-A in regulating the oxygen intake. VEGF-A is dynamically controlled by the HIF-1alpha concentration. If not degraded, HIF-1alpha can bind to the subunit termed HIF-1beta and so
arxiv   +1 more source

Double-Blind, Randomized Trial of Docetaxel Plus Vandetanib Versus Docetaxel Plus Placebo in Platinum-Pretreated Metastatic Urothelial Cancer [PDF]

, 2011
Vandetanib is an oral once-daily tyrosine kinase inhibitor with activity against vascular endothelial growth factor receptor 2 and epidermal growth factor receptor.
Bubley, Glenn J., Buckle, Geoffrey C., Choueiri, Toni K., Eisenberger, Mario A., Hahn, Noah M., Hutson, Thomas E., Jacobus, Susanna, Kantoff, Philip W., Kim, William Y., Morrissey, Stephanie C., Mortazavi, Amir, Petrylak, Daniel P., Quinn, David I., Rosenberg, Jonathan E., Ross, Robert W., Ryan, Christopher W., Sonpavde, Guru, Taplin, Mary-Ellen, Vaishampayan, Ulka, Yu, Evan Y.   +19 more
core   +2 more sources