Results 141 to 150 of about 650,658 (370)
The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems
Asian Journal of Pharmaceutical Sciences, 2019 Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu +4 more
doaj
Journal of Bio-X Research, 2020 . Single-domain antibodies have the characteristics of small molecular weight, strong tissue penetration, and high affinity, and are widely used to construct molecular probes for disease diagnosis and treatment.
Huifang Liu +6 more
doaj +1 more source
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments [PDF]
, 2006 Receptor endocytosis is a fundamental step in controlling the magnitude, duration, and nature of cell signaling events. Confluent endothelial cells are contact inhibited in their growth and respond poorly to the proliferative signals of vascular ...
Dejana, Elisabetta +4 more
core +2 more sources
Metabolic Consequences of Rheumatoid Arthritis
Arthritis Care &Research, EarlyView.Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry +2 more
wiley +1 more source
A Spatial Model of Tumor-Host Interaction: Application of Chemotherapy [PDF]
Math. Biosci. Eng. 6(3):521-545, 2009, 2008 In this paper we consider chemotherapy in a spatial model of tumor growth. The model, which is of reaction-diffusion type, takes into account the complex interactions between the tumor and surrounding stromal cells by including densities of endothelial cells and the extra-cellular matrix.
arxiv
The Potential Role of Oxidative Stress in Reduced Uterine Perfusion Pressure Vascular Reactivity [PDF]
, 2017 Preeclampsia is a hypertensive disease of pregnant women that is known to cause detrimental physiological complications to both the mother and fetus. The hypertension hypothesized to result from endothelial dysfunction may be improved therapeutically by ...
Gindlesberger, Abigail J
core +1 more source
The Role ofBiomechanics in Vascular Endothelial Growth Factor Receptor-2 Signaling [PDF]
, 2022 Angiogenesis, or the growth of new vasculature from existing blood vessels, is widely considered a primary hallmark of cancer progression. When a tumor is small, diffusion is sufficient to receive essential nutrients; however, as the tumor grows a ...
Miller, Bronte
core +1 more source
Advanced Biology, EarlyView.Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi +4 more
wiley +1 more source
Sex Differences in Circulating Progenitor Cells
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundLower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes.
Matthew L. Topel +9 more
doaj +1 more source
Advanced Biology, EarlyView.In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu +12 more
wiley +1 more source