Results 151 to 160 of about 650,658 (370)

Direct activation of NADPH oxidase 2 by 2-deoxyribose-1-phosphate triggers nuclear factor kappa B-dependent angiogenesis. [PDF]

, 2017
Aims: Deoxyribose-1-phosphate (dRP) is a proangiogenic paracrine stimulus released by cancer cells, platelets, and macrophages and acting on endothelial cells.
Anneke Lubben, Brown NS, Caroline P.D. Wheeler-Jones, Dina Vara, Fischer AH, Giordano Pula, Harry Mellor, Hotchkiss KA, Joanna M. Watt, Kate Wicks, Kimberly Mace, Matsushita S, Matthew Burgess, Miyadera K, Schreck R, Shaun Reeksting, Tiago M. Fortunato   +16 more
core   +4 more sources

Mesenchymal Stem Cells‐Derived Extracellular Vesicles Mimetics as Osteoinductive Mediators for Bone Healing

Advanced Functional Materials, EarlyView.
Mesenchymal stem cell‐derived nanoghosts (MSC‐NGs) mimic naturally secreted extracellular vesicles (MSC‐EVs) in structure and physicochemical properties but can be synthesized at more translatable yields. As osteogenic agents, MSC‐NGs demonstrate superior outcomes compared to MSC‐EVs.
Antoine Karoichan, Ling Li, Celine J. Agnes, Bettina M. Willie, Maryam Tabrizian   +4 more
wiley   +1 more source

Pazopanib as first-line therapy for patients with metastatic kidney cancer

Медицинский совет, 2018
Pazopanib (Votrient®) is an oral small-molecule multi-kinase inhibitor that predominantly inhibits vascular endothelial growth factor receptor-1, -2 and -3, platelet-derived growth factor receptor-α and -β and the stem cell factor receptor c-Kit.
B. Ya. Alekseev, I. M. Shevchuk
doaj   +1 more source

Immunolocalization of angiogenic growth factors in the ovine uterus during the oestrus cycle and in response to Steroids [PDF]

, 2018
The vascular changes associated with endometrial maturation in preparation for embryo implantation depend on numerous growth factors, known to regulate key angiogenic events.
Boroujeni, Bridges, Charnock-Jones, Coffelt, Cullinan-Bove, Das, Fan, Gabler, Girling, Grazul-Bilska, Guo, Guo, Heryanto, Hirchenhain, Johnson, Kappou, Kazi, Kazi, Lash, Ma, Maas, Matsumoto, Meduri, Moller, Mueller, Nayak, Nayak, Niklaus, Ponglowhapan, Punyadeera, Raheem, Robinson, Rowe, Ruiz-Gonzalez, Sagsoz, Sagsoz, Shweiki, Tasaki, Thomas, Torry, Tsuzuki, Walter, Winther, Woolf   +43 more
core   +1 more source

Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, EarlyView.
Chiral engineered biomaterials can selectively influence cell behaviors in regenerative medicine. This review covers chiral engineered biomaterials in terms of their fabrication methods, cellular response mechanisms, and applications in directing stem cell differentiation and tissue function.
Yuwen Wang, Xin Zhang, Denghui Xie, Chunying Chen, Zhifeng Huang, Zhong Alan Li   +5 more
wiley   +1 more source

Synthetic Antibody Mimic Peptides [PDF]

, 2017
The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies relative to their respective targets.
Jasti, Bhaskara, Joo, Hyun, Li, Xiaoling, Sachdeva, Sameer, Tsai, Jerry W., Zheng, Yu   +5 more
core   +1 more source

Sorafenib and Thyroid Cancer [PDF]

, 2013
Sorafenib (Nexavar) is a multikinase inhibitor, which has demonstrated both anti-proliferative and anti-angiogenic properties in vitro and in vivo, inhibiting the activity of targets present in the tumor cell [c-RAF (proto-oncogene serine/threonine ...
ANTONELLI, ALESSANDRO, Corrado A, Fallahi P, Ferrari SM, MATERAZZI, GABRIELE, MICCOLI, PAOLO, Santini F, Ulisse S   +7 more
core   +1 more source

A Gym for Cells—Direct Laser Writing of Magnetic Multilayered Micro Actuators for Mechanical Stimulation of Cells

Advanced Functional Materials, EarlyView.
Surface‐attached multilayer micromagnet systems are fabricated by two‐photon crosslinking. The pillar‐shaped micro actuators consist of a soft and flexible surface‐attached cell‐repellent hydrogel layer at the bottom, acting as a hinge and a cell‐adhesive hydrophobic polymer filled with magnetic nanoparticles.
Nicolas Geid, Ayman Husari, Eleonora Galli, Lukas Leffler, Pascal Tomakidi, Jürgen Rühe   +5 more
wiley   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

miR-1233-3p Inhibits Angiopoietin-1-Induced Endothelial Cell Survival, Migration, and Differentiation

Cells
Angiopoietin-1 (Ang-1) and its receptor Tie-2 promote vascular integrity and angiogenesis. MicroRNAs (miRNAs) are involved in the regulation of many cellular functions, including endothelial cell (EC) survival, proliferation, and differentiation. Several
Veronica Sanchez, Sharon Harel, Anas Khalid Sa’ub, Dominique Mayaki, Sabah N. A. Hussain   +4 more
doaj   +1 more source