Results 221 to 230 of about 749,263 (385)

Development of antibody-based c-Met inhibitors for targeted cancer therapy

ImmunoTargets and Therapy, 2015
Dongheon Lee, Eun-Sil Sung, Jin-Hyung Ahn, Sungwon An, Jiwon Huh, Weon-Kyoo You Hanwha Chemical R&D Center, Biologics Business Unit, Daejeon, Republic of Korea Abstract: Signaling pathways mediated by receptor tyrosine kinases (RTKs) and their ...
Lee D, Sung ES, Ahn JH, An S, Huh J, You WK   +5 more
doaj  

(E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth Factor Receptor-2: Synthesis, Computational, and Anticancer Studies. [PDF]

Molecules, 2022
Yousef RG, Elkady H, Elkaeed EB, Gobaara IMM, Al-Ghulikah HA, Husein DZ, Ibrahim IM, Metwaly AM, Eissa IH.   +8 more
europepmc   +1 more source

Vascular endothelial growth factor receptor 2 and downstream p38 mitogen-activated protein kinase are possible candidate markers of intrinsic resistance to adjuvant endocrine treatment in steroid receptor positive breast cancer

, 2010
Barbro Linderholm, Henrik Hellborg, Ulla Johansson, Lambert Skoog, Janne Lehtiö   +4 more
openalex   +2 more sources

Phase I pharmacologic and biologic study of ramucirumab (IMC-1121B), a fully human immunoglobulin G1 monoclonal antibody targeting the vascular endothelial growth factor receptor-2.

Journal of Clinical Oncology, 2010
J. Spratlin, R. Cohen, Matthew J Eadens, L. Gore, D. Camidge, S. Diab, S. Leong, C. O’Bryant, L. Chow, N. Serkova, Neal J. Meropol, N. Lewis, E. Chiorean, F. Fox, H. Youssoufian, E. Rowinsky, S. Eckhardt   +16 more
semanticscholar   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Comparison of vascular endothelial growth factor/vascular endothelial growth factor receptor 2 expression and its relationship to tumor cell proliferation in canine epithelial and mesenchymal tumors. [PDF]

J Vet Med Sci, 2022
Kimura M, Miyahara K, Yamasaki M, Uchida N.   +3 more
europepmc   +1 more source

Higher expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) and metalloproteinase-9 (MMP-9) in a rat model of peritoneal endometriosis is similar to cancer diseases [PDF]

, 2010
Daniel Escorsim Machado, Plínio Tostes Berardo, Celia Yelimar Palmero, Luiz Eurico Nasciutti   +3 more
openalex   +1 more source

Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions

Advanced Healthcare Materials, EarlyView.
Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi, Lisa A. Krattiger, Magdalini Kanari, Mira A. Jacobs, Lukas O. Moser, Mark W. Tibbitt, Cornelia Halin, Martin Ehrbar   +7 more
wiley   +1 more source

Soluble vascular endothelial growth factor receptor-2 serves as a predictor of cardiovascular events in patients with chronic heart failure [PDF]

, 2013
Moritake Iguchi, Hiromichi Wada, Masaharu Akao, Shogo Ura, Nobutoyo Masunaga, Mitsuru Ishii, Takashi Unoki, Mitsuru Abe, Akira Shimatsu, Koji Hasegawa   +9 more
openalex   +1 more source

Plasma‐Polymerized Nanoparticles Presenting Fibrillin‐1 Drive Rapid Re‐Endothelialization of Vascular Grafts

Advanced Healthcare Materials, EarlyView.
Commercial vascular grafts are made from ePTFE, a highly hydrophobic, foreign material that fails at a high rate in small‐diameter applications. Plasma polymer nanoparticles (PPN) are a versatile material functionalisation tool, used here to present fibrillin‐1 fragment PF8 on the graft surface.
Bob S. L. Lee, Yuen Ting Lam, Alex H. P. Chan, Praveesuda L. Michael, Timothy C. Mitchell, Jui Chien Hung, Miguel Santos, Khoon S. Lim, Richard P. Tan, Steven G. Wise   +9 more
wiley   +1 more source