Results 331 to 340 of about 650,658 (370)

Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain

Brain Research, 2002
Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within its developing cerebral cortex. In this study, with the aim of elucidating the mechanisms of vascular involvement during brain impairment in Duchenne muscular distrophy (DMD), we have correlated the ...
NICO, Beatrice, CORSI, Patrizia, RIBATTI, Domenico, VACCA, Angelo, RONCALI L.   +4 more
openaire   +3 more sources

Endothelial Cell Death and Decreased Expression of Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor 2 in Emphysema

American Journal of Respiratory and Critical Care Medicine, 2001
Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells and a decreased expression of lung vascular endothelial growth factor (VEGF) and its receptor 2 (VEGF R2).
Yasunori Kasahara, David A. Lynch, Carlyne D. Cool, Norbert F. Voelkel, Rubin M. Tuder, Sonia C. Flores   +5 more
openaire   +2 more sources

Discovery of Potent Vascular Endothelial Growth Factor Receptor‐2 Inhibitors

ChemMedChem, 2009
AbstractSubstantial evidence over the last decades has implicated uncontrolled angiogenesis with various pathological states, including cancer. Vascular endothelial growth factor (VEGF) plays a critical role in its regulation. Because the tyrosine kinase VEGF receptor‐2 (VEGFR‐2) is the major mediator of the mitogenic, angiogenic, and permeability ...
Dionisios Vourloumis, Maria Belimezi, Athanasios Papakyriakou, Michael Karpusas, Maria E. Katsarou   +4 more
openaire   +3 more sources

Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in the chick embryo area vasculosa.

The Histochemical journal, 2001
Vascular endothelial growth factor is an angiogenic factor in vivo and in vitro that plays a crucial role in the control of blood vessel development and in pathological angiogenesis. The vascularized extraembryonic membranes of the chick embryo include the area vasculosa and the chorioallantoic membrane. In this study, we investigated the expression of
NICO, Beatrice, VACCA, Angelo, DE GIORGIS M, RONCALI L, RIBATTI, Domenico   +4 more
openaire   +3 more sources

Role of vascular endothelial growth factor receptor 1 and vascular endothelial growth factor receptor 2 in the vasodilator response to vascular endothelial growth factor in the neonatal piglet lung

Critical Care Medicine, 2005
Vascular endothelial growth factor (VEGF) regulates vascular proliferation and causes vasodilation. In the pulmonary circulation, the vasorelaxing effect of VEGF has been attributed to nitric oxide, whereas in other vascular beds, prostacyclin and other mechanisms are also involved. This vascular effect follows binding to two receptors, VEGF receptor 1
Sophie Nadeau, Thérèse Perreault, Johanne Baribeau, Annie Janvier   +3 more
openaire   +3 more sources

A new PET tracer specific for vascular endothelial growth factor receptor 2 [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2007
Noninvasive positron emission tomography (PET) imaging of vascular endothelial growth factor receptor 2 (VEGFR-2) expression could be a valuable tool for evaluation of patients with a variety of malignancies, and particularly for monitoring those undergoing antiangiogenic therapies that block VEGF/VEGFR-2 function.
Kai Chen, Xiaoyuan Chen, Weibo Cai, Amir Kashefi, Lina He, Hui Wang, Zibo Li   +6 more
openaire   +2 more sources

Vascular endothelial growth factor-A, vascular endothelial growth factor receptor-2 and angiopoietin-2 expression in the mouse choroid plexuses

Brain Research, 2004
In this study, for the first time, we investigated about the localization of VEGF-A, VEGFR-2 and Ang-2 in the choroid plexuses of the adult mouse by Western blot and immunohistochemistry. Results showed that VEGF-A stained epithelial cells, while anti-VEGFR-2 and -Ang-2 antibodies stained endothelial cells.
Nico, Beatrice, De Giorgis, Michela, Vacca, Angelo, Roncali, Luisa, Ribatti, Domenico, MANGIERI, DOMENICA, CORSI, PATRIZIA   +6 more
openaire   +4 more sources

Changes in circulating levels of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 after carotid endarterectomy

International Journal of Molecular Medicine, 2004
It has been shown that vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR-2) are upregulated in severe carotid stenosis. However, it is unknown whether carotid endarterectomy (CEA) affects serum level of these molecules.
Papalambros, E., Georgopoulos, S., Sigala, F., Vourliotakis, G., Chrisostomidis, G., Venetsanou, K., Hadjoulis, G., Felekouras, E., Bastounis, E.   +8 more
openaire   +3 more sources

Regulation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1) Expression in Vascular Endothelial Cells

Experimental Cell Research, 1998
We have previously reported the existence of a synergistic interaction between vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the induction of angiogenesis in vitro. Here we demonstrate that bFGF increases VEGF receptor-2 (VEGFR-2/Flk-1) expression: mRNA levels were increased by 4.5- to 8.0-fold and total protein
Michael S. Pepper, Stefano J. Mandriota
openaire   +3 more sources

ARHGEF26: a new player in vascular endothelial growth factor receptor 2 trafficking

Cardiovascular Research, 2022
International ...
Anne-Clémence Vion, Gervaise Loirand
openaire   +3 more sources