Results 341 to 350 of about 749,263 (385)

Endothelial cell death and decreased expression of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 in emphysema.

American Journal of Respiratory and Critical Care Medicine, 2001
Emphysema due to cigarette smoking is characterized by a loss of alveolar structures. We hypothesize that the disappearance of alveoli involves apoptosis of septal endothelial cells and a decreased expression of lung vascular endothelial growth factor (VEGF) and its receptor 2 (VEGF R2).
Y. Kasahara, R. Tuder, C. Cool, D. Lynch, S. Flores, N. Voelkel   +5 more
semanticscholar   +3 more sources

A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities* [PDF]

Journal of Biological Chemistry, 1998
The vascular endothelial growth factor (VEGF) and the VEGF-C promote growth of blood vessels and lymphatic vessels, respectively. VEGF activates the endothelial VEGF receptors (VEGFR) 1 and 2, and VEGF-C activates VEGFR-3 and VEGFR-2. Both VEGF and VEGF-C are also potent vascular permeability factors.
V. Joukov, Vijay Kumar, T. Sorsa, E. Arighi, H. Weich, O. Saksela, K. Alitalo   +6 more
semanticscholar   +3 more sources

Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain

Brain Research, 2002
Recent data have demonstrated that vascular endothelial growth factor (VEGF) is expressed by subsets of neurons, coincident with angiogenesis within its developing cerebral cortex. In this study, with the aim of elucidating the mechanisms of vascular involvement during brain impairment in Duchenne muscular distrophy (DMD), we have correlated the ...
NICO, Beatrice, CORSI, Patrizia, RIBATTI, Domenico, VACCA, Angelo, RONCALI L.   +4 more
openaire   +2 more sources

Discovery of Potent Vascular Endothelial Growth Factor Receptor‐2 Inhibitors

ChemMedChem, 2009
AbstractSubstantial evidence over the last decades has implicated uncontrolled angiogenesis with various pathological states, including cancer. Vascular endothelial growth factor (VEGF) plays a critical role in its regulation. Because the tyrosine kinase VEGF receptor‐2 (VEGFR‐2) is the major mediator of the mitogenic, angiogenic, and permeability ...
Athanasios, Papakyriakou, Maria E, Katsarou, Maria, Belimezi, Michael, Karpusas, Dionisios, Vourloumis   +4 more
openaire   +2 more sources

Vascular Endothelial Growth Factor and Vascular Endothelial Growth Factor Receptor-2 Expression in the Chick Embryo Area Vasculosa

The Histochemical Journal, 2001
Vascular endothelial growth factor is an angiogenic factor in vivo and in vitro that plays a crucial role in the control of blood vessel development and in pathological angiogenesis. The vascularized extraembryonic membranes of the chick embryo include the area vasculosa and the chorioallantoic membrane. In this study, we investigated the expression of
NICO, Beatrice, VACCA, Angelo, DE GIORGIS M, RONCALI L, RIBATTI, Domenico   +4 more
openaire   +2 more sources

Regulation of Vascular Endothelial Growth Factor Receptor-2 (Flk-1) Expression in Vascular Endothelial Cells

Experimental Cell Research, 1998
We have previously reported the existence of a synergistic interaction between vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the induction of angiogenesis in vitro. Here we demonstrate that bFGF increases VEGF receptor-2 (VEGFR-2/Flk-1) expression: mRNA levels were increased by 4.5- to 8.0-fold and total protein
M S, Pepper, S J, Mandriota
openaire   +2 more sources

Vascular endothelial growth factor receptor-2 inhibition in experimental murine colitis

Journal of Surgical Research, 2013
In the setting of inflammatory bowel disease, inflammation is associated with a simultaneous increase in angiogenesis; moreover, elevated vascular endothelial growth factor (VEGF) levels implicate angiogenesis as a pathologic contributor to disease severity.
Leslie, Knod, Eileen C, Donovan, Artur, Chernoguz, Kelly M, Crawford, Mary R, Dusing, Jason S, Frischer   +5 more
openaire   +2 more sources

Olive oil compounds inhibit vascular endothelial growth factor receptor-2 phosphorylation

Experimental Cell Research, 2014
Vascular endothelial growth factor (VEGF) triggers crucial signaling processes that regulate tumor angiogenesis and, therefore, represents an attractive target for the development of novel anticancer therapeutics. Several epidemiological studies have confirmed that abundant consumption of foods from plant origin is associated with reduced risk of ...
Sylvie, Lamy, Amira, Ouanouki, Richard, Béliveau, Richard R, Desrosiers   +3 more
openaire   +2 more sources

Vascular Endothelial Growth Factor Receptor 2 Blockade Disrupts Postnatal Lung Development

American Journal of Respiratory Cell and Molecular Biology, 2005
Vascular endothelial growth factor (VEGF) is necessary for normal postnatal lung development and may underlie the structural lung damage that follows hyperoxic exposure. To determine the individual roles of VEGF receptors (VEGFR) 2 and 1 on postnatal lung growth, neonatal mice were treated with neutralizing antibodies to VEGFR-2 (DC101) or VEGFR-1 (MF1)
Sharon A, McGrath-Morrow, Cecilia, Cho, Chung, Cho, Lijie, Zhen, Daniel J, Hicklin, Rubin M, Tuder   +5 more
openaire   +2 more sources

Placental Growth Factor and Vascular Endothelial Growth Factor Receptor-2 in Human Lung Development

Pediatrics, 2008
OBJECTIVE. We examined the pulmonary expression of 2 proangiogenic factors, namely, placental growth factor and vascular endothelial growth factor receptor-2, during lung development and acute and chronic lung injury in newborn infants.METHODS. Six groups were included in an immunohistochemical study of placental growth factor and vascular endothelial ...
Joakim, Janér, Sture, Andersson, Caj, Haglund, Riitta, Karikoski, Patrik, Lassus   +4 more
openaire   +2 more sources