Results 71 to 80 of about 1,018,275 (289)

Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk [PDF]

, 2012
We have previously shown that injury-induced neointima formation was rescued by adenoviral-Nogo-B gene delivery. Integrase-competent lentiviral vectors (ICLV) are efficient at gene delivery to vascular cells but present a risk of insertional mutagenesis.
Sessa, W.C., Chick, H.E., Kane, N.M., Baker, A.H., Thrasher, A.J., Alba, R., Fronza, R., McDonald, R.A., Delles, C., Schmidt, M., Nowrouzi, A.   +10 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Neurologic Manifestations of Long COVID Affect Adult Females More Severely Than Males

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize differences in neurologic manifestations of postacute sequelae of SARS‐CoV‐2 infection (Neuro‐PASC) between females and males. Methods Cross‐sectional study of the first consecutive 261 posthospitalization Neuro‐PASC (PNP) and 2068 nonhospitalized Neuro‐PASC (NNP) patients evaluated at the Neuro‐COVID clinic between ...
Hannah Kopinsky, Melissa Lopez, Janet Miller, Millenia Jimenez, Eric M. Liotta, Igor J. Koralnik   +5 more
wiley   +1 more source

Fabrication of strong, bioactive vascular grafts with PCL/collagen and PCL/silica bilayers for small-diameter vascular applications

Materials & Design, 2019
In vascular surgical applications, small-diameter vascular grafts made from synthetic polymers are rarely commercialized, owing to delayed reendothelialization and subsequent thrombus formation and occlusion.
Suhyung Park, Jinyoung Kim, Min-Kyu Lee, Cheonil Park, Hyun-Do Jung, Hyoun-Ee Kim, Tae-Sik Jang   +6 more
doaj   +1 more source

Orthotopic heart transplantation with reconstruction of persistent left superior vena cava

Surgical Case Reports, 2020
Background Persistent left superior vena cava is a not uncommon congenital vascular abnormality. We report a case of heart transplantation with reconstruction of persistent left superior vena cava using a prosthetic vascular graft. Case presentation A 20-
Kazuma Handa, Hiroki Hata, Koichi Toda, Shigeru Miyagawa, Yasushi Yoshikawa, Daisuke Yoshioka, Yoshiki Sawa   +6 more
doaj   +1 more source

Graft-preserving treatment for vascular graft infected with Staphylococcus aureus with antibiotic-releasing porous apatite ceramic in the rabbit [PDF]

, 2003
ObjectiveThis study was undertaken to investigate whether infection of a vascular graft with Staphylococcus aureus can be treated in situ by applying antibiotic-loaded porous apatite ceramic, in a rabbit model.MethodsTeicoplanin (TEIC) was loaded onto a ...
Hisashi Iwata, Murase, Katsutoshi, Takagi, Hisato, Hisato Takagi, Katsutoshi Murase, Tetsu Sago, Yoshiaki Kawamura, Iwata, Hisashi, Mori, Yoshio, Hirose, Hajime, Hajime Hirose, Sago, Tetsu, Yoshio Mori, Kawamura, Yoshiaki   +13 more
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source

Rheumatoid arthritis, frailty, and outcomes of surgical hospitalizations: A national population‐based analysis

Arthritis Care &Research, Accepted Article.
OBJECTIVE Hospitalization, particularly for surgery, represents a period of heightened stress. We evaluated how frailty attenuates the association of rheumatoid arthritis (RA) with negative health outcomes after elective non‐cardiac surgery. METHODS We conducted a cross‐sectional study using the National Inpatient Sample (2018 to 2020), including ...
Ali Yazdanyar, Joshua Baker, Katherine D Wysham, Mohammed Yousufuddin, Farah Acher Kaiksow, Michael M. Ward   +5 more
wiley   +1 more source

Evaluation of the patency rate and endothelialization of a poly-ε-caprolactone, nanofiber sheet-based vascular graft using a rat abdominal aortic implantation model

Frontiers in Surgery
IntroductionThe global increase in cardiovascular diseases has resulted in an augmented development of artificial small-caliber vascular grafts used in bypass graft surgeries, such as coronary and distal artery bypass graft surgeries.
Yuta Kikuchi, Naohiro Wakabayashi, Daikelly I. Braghirolli, Patricia Pranke, Hiroyuki Kamiya, Kyohei Oyama   +5 more
doaj   +1 more source

Early renal arterial rupture and arterial pseudoaneurysm in graft kidneys from the same deceased donor

Tzu Chi Medical Journal, 2018
Vascular complications are serious problems after kidney transplantation. An aneurysm or rupture in a graft artery is a rare but potentially devastating complication, which may lead to renal function impairment, graft loss, or even death.
Yu-Hua Lin, Chun-Hou Liao, Bing-Jun Jiang, Tzu-Hung Chen   +3 more
doaj   +1 more source