Results 1 to 10 of about 745,031 (167)

Physiological and pathological characteristics of vascular endothelial injury in diabetes and the regulatory mechanism of autophagy

Frontiers in Endocrinology, 2023
Vascular endothelial injury in diabetes mellitus (DM) is the major cause of vascular disease, which is closely related to the occurrence and development of a series of vascular complications and has a serious negative impact on a patient’s health and ...
Hanyu Liu, Xueru Wang, Hong Gao, Hong Gao, Chan Yang, Chunguang Xie, Chunguang Xie   +6 more
doaj   +3 more sources

Vascular Stem/Progenitor Cells in Vessel Injury and Repair

Frontiers in Cardiovascular Medicine, 2022
Vascular repair upon vessel injury is essential for the maintenance of arterial homeostasis and function. Stem/progenitor cells were demonstrated to play a crucial role in regeneration and replenishment of damaged vascular cells during vascular repair ...
Jiaping Tao, Jiaping Tao, Jiaping Tao, Xuejie Cao, Xuejie Cao, Xuejie Cao, Baoqi Yu, Baoqi Yu, Baoqi Yu, Aijuan Qu, Aijuan Qu, Aijuan Qu   +11 more
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Major vascular injury during gynecologic cancer surgery

Gynecologic Oncology Reports, 2021
Objective: Vascular injury during major gynecologic cancer surgery is a rare but potentially fatal complication. The purpose of this study was to review our experience with major vascular injury during gynecologic cancer surgery.
Andrea L. Buras, Jing Yi Chern, Hye Sook Chon, Mian M. Shahzad, Robert M. Wenham, Mitchel S. Hoffman   +5 more
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Effects of anesthetics on cardiac function test in mouse model of pressure overload-induced heart failure

陆军军医大学学报, 2022
Objective To compare the effects of four common anesthetics on cardiac function test in pressure overload-induced heart failure mice. Methods Eight-week-old male C57/BL6 mice (n=120) with a body weight of 20~25 g were selected to establish a mouse model ...
TANG Fuqin, REN Meiying, ZHU Yu, JIAN Zhao, XIAO Yingbin   +4 more
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Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress

Scientific Reports, 2023
To provide a theoretical basis for the prevention and treatment of atherosclerosis (As), the current study aimed to investigate the mechanism underlying the effect of homocysteine (Hcy) on inducing the lipid deposition and foam cell formation of the ...
Xiuyu Wang, Xing Ma, Yue Zeng, Lingbo Xu, Minghao Zhang   +4 more
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Cooperation between NSPc1 and DNA methylation represses HOXA11 expression and promotes apoptosis of trophoblast cells during preeclampsia

Acta Biochimica et Biophysica Sinica, 2023
Accumulating evidence has shown that the apoptosis of trophoblast cells plays an important role in the pathogenesis of preeclampsia, and an intricate interplay between DNA methylation and polycomb group (PcG) protein-mediated gene silencing has been ...
Xie Lin, Ding Ning, Sheng Siqi, Zhang Honghong, Yin He, Gao Lina, Zhang Hui, Ma Shengchao, Yang Anning, Li Guizhong, Jiao Yun, Shi Qing, Jiang Yideng, Zhang Huiping   +13 more
doaj   +1 more source

miR-30a-5p promotes glomerular podocyte apoptosis via DNMT1-mediated hypermethylation under hyperhomocysteinemia

Acta Biochimica et Biophysica Sinica, 2021
Abnormal elevation of homocysteine (Hcy) level is closely related to the development and progression of chronic kidney disease (CKD), with the molecular mech2anisms that are not fully elucidated.
Ding Ning, Xie Lin, Ma Fei, Ma Shengchao, Xiong Jiantuan, Lu Guanjun, Zhang Huiping, Jiang Yideng   +7 more
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A novel lncRNA FPASL regulates fibroblast proliferation via the PI3K/AKT and MAPK signaling pathways in hypertrophic scar

Acta Biochimica et Biophysica Sinica, 2022
Hypertrophic scar is a problem for numerous patients, especially after burns, and is characterized by increased fibroblast proliferation and collagen deposition.
Ma Fang, Shen Jiangyong, Zhang Hui, Zhang Zhenghao, Yang Anning, Xiong Jiantuan, Jiao Yun, Bai Zhigang, Ma Shengchao, Zhang Huiping, Jiang Yideng   +10 more
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LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar

Acta Biochimica et Biophysica Sinica, 2022
Long noncoding RNAs (lncRNAs) are increasingly being implicated as key regulators of cell proliferation, apoptosis, and differentiation. However, the molecular mechanisms of specific lncRNAs in the context of hypertrophic scar remain largely unclear ...
Wu Kai, Ma Fang, Shen Jiangyong, Zhang Hui, Wan Yu, He Xi, Yang Anning, Xiong Jiantuan, Jiao Yun, Bai Zhigang, Ma Shengchao, Jiang Yideng, Zhang Huiping, Hao Yinju   +13 more
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Destabilization of Lysophosphatidic Acid Receptor 1 Reduces Cytokine Release and Protects Against Lung Injury

EBioMedicine, 2016
Lysophosphatidic acid receptor 1 (LPA1) is a druggable target for treating pulmonary inflammatory diseases. However, the molecular regulation of LPA1 stability, a factor that critically impacts its biological activity, remains largely unknown.
Jing Zhao, Jianxin Wei, Su Dong, Rachel K. Bowser, Lina Zhang, Anastasia M. Jacko, Yutong Zhao   +6 more
doaj   +1 more source