Results 51 to 60 of about 112,017 (259)

Effect of Chlorothiazide on Vascular Reactivity.

Experimental Biology and Medicine, 1958
SummaryChlorothiazide (Diuril), an orally effective diuretic, has been shown to decrease arterial pressure response to injections of norepinephrine, epinephrine and isopropylnorepinephrine in the anesthetized dog. The possible relationship of this finding to the reported hypotensive action of the compound is discussed.
W R, BEAVERS, W P, BLACKMORE
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Effect of tamoxifen on the coronary vascular reactivity of spontaneously hypertensive female rats

Brazilian Journal of Medical and Biological Research, 2011
Tamoxifen has been associated with a reduction in the incidence of myocardial infarction. However, the effects of tamoxifen on coronary reactivity have not been fully elucidated.
M.V. Borgo, A.B. Lopes, S.A. Gouvêa, W.G. Romero, M.R. Moyses, N.S. Bissoli, G.R. Abreu   +6 more
doaj   +3 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Association between NT-pro-BNP levels and endothelial dysfunction assessed by digital thermal monitoring in patients with coronary artery disease

Frontiers in Cardiovascular Medicine
ObjectiveEndothelial dysfunction is a key mechanism in the progression of coronary artery disease (CAD). N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), a biomarker of myocardial wall stress, has been associated with vascular abnormalities beyond
Ji-Hung Wang, Ji-Hung Wang, Ji-Hung Wang, I-Min Su, I-Min Su, I-Min Su, Bang-Gee Hsu, Bang-Gee Hsu, Bang-Gee Hsu, Bang-Gee Hsu   +9 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Increased serum galectin-3 level is associated with endothelial dysfunction and cardiovascular events in patients with hypertension

Heliyon
Background: Endothelial dysfunction can lead to various harmful cardiovascular complications. The importance of galectin-3 (Gal-3) has been proposed in some cardiac diseases related to chronic inflammation.
Hui-Sheng Wang, Bang-Gee Hsu, Ji-Hung Wang, Chiu-Fen Yang   +3 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Clinical Significance of Acute and Serial Platelet Function Testing in Acute Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundWe sought to investigate the clinical implications of platelet reactivity to aspirin and the variability in the platelet reactivity to aspirin during acute periods for the risk of vascular events in patients with acute ischemic stroke.
Joon‐Tae Kim, Kang‐Ho Choi, Man‐Seok Park, Ji Sung Lee, Jeffrey L. Saver, Ki‐Hyun Cho   +5 more
doaj   +1 more source