Results 81 to 90 of about 1,180,293 (286)

Vascular reactivity of the brachial artery in the study population.

, 2014
Data are shown as median (interquartile range ...
Sandra Pizarro (623237), Marta Díez (623241), Marta Sitges (241368), Víctor I. Peinado (623239), Olga Tura-Ceide (623240), Isabel Blanco (623242), Jordi Petriz (345955), Pedro Marín (623244), Joan Albert Barberà (489699), Josep Roca (207143), Yolanda Torralba (623243), Jéssica García-Lucio (623238)   +11 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Changes in Immune‐Inflammation Status and Prognosis in Pregnancy‐Related Cerebral Venous Thrombosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Distinguishing pathological changes from physiological adaptations in pregnancy‐related cerebral venous thrombosis (CVT) is clinically challenging. This study aimed to characterize coagulation, immune‐inflammation, and dehydration status in these patients and assess their prognostic value.
Xiaoming Zhang, Zilin Xu, Ran Duan, Chunxiao Lu, Da Zhou, Chen Zhou, Ran Meng, Xunming Ji   +7 more
wiley   +1 more source

Cell death process associated with the renin-angiotensin-aldosterone system

Revista Médica del Hospital General de México
The renin-angiotensin-aldosterone system (RAAS) is a crucial regulator of blood pressure and fluid balance. This metabolic pathway plays an important role in the genesis of cardiovascular and renal diseases.
Emiliano Gómez-Montañez, Yareli L. Rojas-Salazar, Alicia Sánchez-Mendoza, María Sánchez-Aguilar   +3 more
doaj  

Exercise training improves vascular reactivity in ovariectomized rats subjected to myocardial infarction.

PLoS ONE, 2019
The aim of this study was to evaluate the effects of exercise training (ET) on the aortic vascular reactivity of ovariectomized and infarcted rats. The animals were divided into 5 groups: Control, Ovariectomized + SHAM sedentary (OVX+SHAMSED), OVX+SHAM ...
Suelen Guedes de Oliveira, Erick Roberto Gonçalves Claudio, Simone Alves de Almeida, Vinicius Mengal, Fabricio Bragança da Silva, Nyam Florêncio Silva, Helder Mauad, Glaucia Rodrigues de Abreu   +7 more
doaj   +1 more source

Clinical Significance of Acute and Serial Platelet Function Testing in Acute Ischemic Stroke

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundWe sought to investigate the clinical implications of platelet reactivity to aspirin and the variability in the platelet reactivity to aspirin during acute periods for the risk of vascular events in patients with acute ischemic stroke.
Joon‐Tae Kim, Kang‐Ho Choi, Man‐Seok Park, Ji Sung Lee, Jeffrey L. Saver, Ki‐Hyun Cho   +5 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Anticoagulation Treatment Response Among Phenotypic ESUS Clusters: Evidence From CASPR

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate treatment effect heterogeneity across phenotypic clusters of patients with cryptogenic embolic stroke using causal inference methods. Methods From a retrospective, multicenter cohort of patients with cryptogenic embolic stroke, we estimated the treatment effect of anticoagulation versus antiplatelet therapy in patients ...
Elena Badillo Goicoechea, Patrick Ellsworth, James E. Siegler, James R. Brorson, Christina M. Lineback, Frank G. Conyers, Deborah Kerrigan, Kelsey Eklund, Shadi Yaghi, Farid Khasiyev, Emiliya Melkumova, Collin J. Culbertson, Marissa D'Souza, Dinesh V. Jillella, Patrick Glover, Hassan Aboul‐Nour, Fadi Nahab, Mahan Shahrivari, Simona Nedelcu, David S. Liebeskind, Matthew M. Smith, Aaron Rothstein, Anna Bowman, Alicia Zha, Narendra Kala, Ahmad Abu Qdais, Sami Al Kasab, Mudassir Farooqui, Diana Rojas‐Soto, Yasmin Aziz, Franziska Herpich, Jean‐Philippe Daniel, Sean L. Thompson, Vivek Patel, Thanh N. Nguyen, Siddharth Sehgal, Wenzheng Yu, Wayneho Kam, Russel Van Coevering, Oana M. Dumitrascu, Muhammad Alvi, Balaji Krishnaiah, Setareh Salehi Omran, Guillermo Linares, Eesha Singh, Hamid Ali, Mary Penckofer, Jesse M. Thon, Shani Mannion, Dalia Chahien, Lucia Chen, Fawad Talat, Mehdi Abbasi, Richa Sharma   +53 more
wiley   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Minor strokes may be associated with early neurological deterioration (END) and disabilities. The objective was to investigate the role of serum glial fibrillary acidic protein (GFAP) levels in predicting END. Methods Data originated from a multicenter cohort study conducted prospectively.
Jie Zhou, Yang Qu, Reziya Abuduxukuer, Peng Zhang, Ting Wang, Jian‐Hua Gao, De‐Wang Pan, Zhi‐Mei Yuan, Chun‐Ying Li, Li‐Ping Chen, Jin‐Hua Chen, Ji‐Liang Gu, An‐Ying Wang, Li‐Gang Jiang, Liang Liu, Yong‐Fei Jiang, Chun‐Fei Wang, Yan Jia, Hong Xin, Chun‐Li Jiang, Ying‐Bin Qi, Xue‐Feng Hu, Song Li, Hang Jin, Zhen‐Ni Guo, Yi Yang, on behalf of the Biomarkers of Brain Injury Investigator Study Group, Lijuan Wang, Ting Wang, Jianhua Gao, Dewang Pan, Zhimei Yuan, Chunying Li, Liping Chen, Jinhua Chen, Jiliang Gu, Anying Wang, Ligang Jiang, Liang Liu, Yongfei Jiang, Chunfei Wang, Yan Jia, Hong Xin, Chunli Jiang, Yingbin Qi, Xuefeng Hu   +45 more
wiley   +1 more source