Results 81 to 90 of about 5,143,177 (255)

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Mechanisms of Enhanced Vascular Reactivity in Preeclampsia

, 2011
Preeclamptic women have enhanced blood pressure response to angiotensin II and extensive systemic vascular infiltration of neutrophils. Neutrophils release reactive oxygen species that might activate the RhoA kinase pathway to enhance vascular reactivity.
Nikita Mishra, Scott W. Walsh, William H. Nugent, Sunila Mahavadi   +3 more
core   +1 more source

Reduction of vascular reactivity in rat aortas following pilocarpine-induced status epilepticus

, 2023
Objective: The authors investigated changes in vascular reactivity in rats following pilocarpine-induced status epilepticus. Method: Male Wistar rats weighing between 250g and 300g were used.
Karolini Zuqui Nunes, Nunes, Karolini Zuqui, Scorza, Fulvio Alexandre, Fulvio Alexandre Scorza, Vassallo, Dalton Valentim, Cavalheiro, Esper Abrão, Esper Abrão Cavalheiro, Dalton Valentim Vassallo   +7 more
core   +1 more source

Relationship between adipokines, inflammation, and vascular reactivity in lean controls and obese subjects with metabolic syndrome Relação entre as adipocinas, inflamação e reatividade vascular em controles magros e pacientes obesos com síndrome metabólica

Clinics, 2006
PURPOSE: Metabolic syndrome is an important risk factor for cardiovascular disease. Adipokines interfere with insulin action and endothelial cell function.
Luciana Bahia, Luiz Guilherme Aguiar, Nivaldo Villela, Daniel Bottino, Amelio F. Godoy-Matos, Bruno Geloneze, Marcos Tambascia, Eliete Bouskela   +7 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

The Vascular Quality Initiative Cardiac Risk Index for prediction of myocardial infarction after vascular surgery

, 2016
OBJECTIVE: The objective of this study was to develop and to validate the Vascular Quality Initiative (VQI) Cardiac Risk Index (CRI) for prediction of postoperative myocardial infarction (POMI) after vascular surgery.
Schanzer, Andres, Scali, Salvatore T., Bertges, Daniel J., Vascular Quality Initiative, Goodney, Philip P., Neal, Dan, Eldrup-Jorgensen, Jens, Cronenwett, Jack L.   +7 more
core   +1 more source

The role of endothelia receptor antagonism in collar-induced intimal thickening and vascular reactivity changes in rabbits

, 2005
Intimal thickening, due to smooth muscle cell migration and proliferation, is considered to be one of the major components of vascular proliferative disorders such as atherosclerosis and restenosis. One experimental model, resulting in intimal thickening
Ozkal, S, İŞLEKEL, GÜL HÜRAY, Kerry, Z, Turkseven, S, Ozer, E, Sozer, GO, Oktay, GÜLGÜN, Oktay, G, Ozkal, SERMİN, Reel, B, Tanriverdi, S, Islekel, H, Ozkal S., Kerry Z., Reel B., Islekel H., Ozer E., Oktay G., Turkseven S., Sozer G.O., Tanriverdi S.   +20 more
core   +2 more sources

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Growth hormone replacement therapy in adults with growth hormone deficiency improves vascular reactivity

, 1999
Patients with adult growth hormone (GH) deficiency are thought to be of increased risk of cardiovascular disease. Impaired vascular reactivity to endothelium derived nitric oxid (NO) is an early event in the development of atherosclerosis.
Russell-Jones, D L, Christ, E R, Sönksen, P H, Russel-Jones, D L, Chowienczyk, P J, Peter H. Sönksen, Emanuel R. Christ, Philip J. Chowienczyk, David L. Russel-Jones   +8 more
core   +1 more source