Results 131 to 140 of about 1,402,658 (304)

The dual non-competitive CXCR1/2 inhibitor ladarixin impairs neutrophil extravasation without altering intravascular adhesion

Haematologica
In many acute and chronic inflammatory disorders, recruitment of neutrophils plays a critical role in preventing disease severity and ensuring survival. On the other hand, neutrophil accumulation during inflammation can also favor disease progression in
Matteo Napoli, Sebastian Sitaru, Agnes Budke, Anna Kammerl, Georgia Querner, Roland Immler, Ina Rohwedder, Sonja Seifert, Bartolo Ferraro, Ludwig Weckbach, Sergio Catz, Andrea Aramini, Pier Giorgio Amendola, Marcello Allegretti, Riccardo Bertini, Monika Pruenster, Markus Sperandio   +16 more
doaj   +1 more source

Positive Affect is Associated with Better Physical Function in Early Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤ 24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir, Jing Song, Lutfiyya N. Muhammad, Wendy Marder, Kevin Deane, Clifton Bingham, Lisa A. Mandl, Robert Edwards, Judith T. Moskowitz, Yvonne C. Lee   +9 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Leukotriene Receptors: Crucial Components in Vascular Inflammation

The Scientific World Journal, 2007
The accumulation of immune cells during vascular inflammation leads to formation of leukotrienes (LTs). While macrophages represent a major source of LT biosynthesis in the proximity of the vascular wall, activated T lymphocytes may, in addition, play a ...
Magnus Bäck
doaj   +1 more source

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

UA3/8/6 Minority Recruitment & Retention Plan [PDF]

, 1992
Minority Recruitment & Retention Plan submitted to President Thomas Meredith by the Task Force on Minority Recruitment and ...
WKU Task Force on Minority Recruitment & Retention
core  

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

Advanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn, Gyu Tae Park, Dongjun Lee, Sik Yoon, Sae‐Ock Oh, Jae Ho Kim, Byoung Soo Kim   +6 more
wiley   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Vascular risk and depression in outpatients at Groote Schuur Hospital memory clinic [PDF]

, 2009
Includes bibliographical references (leaves 59-67).Background and Objective: Depression in the elderly has been linked with stroke, and with white matter lesions, particularly in frontal-subcortical regions responsible for mood regulation.
Kinnear, H
core  

Nuclear Factor kappa B-Mediated Transactivation of Telomerase Prevents Intimal Smooth Muscle Cell From Replicative Senescence During Vascular Repair

, 2010
Objective-To gain insights into mechanisms by which intimal hyperplasia interferes with the repair process by investigating expression and function of the catalytic telomerase reverse transcriptase (TERT) subunit after vascular injury.
Maria E. Johansson, Jingyi Ren, De-xiu Bu, F. Brad Johnson, Kristina Edfeldt, Johnson, F. Brad, Ren, Jingyi, Xu, Da-wei, Edfeldt, Kristina, Zhong-qun Yan, Johansson, Maria E., Johnson, FB, Johansson, ME, Yan, Z-Q, Ren, J, Bu, D-X, Da-wei Xu, Yan, Zhong-qun, Xu, D-W, Bu, De-xiu, Edfeldt, K,   +20 more
core   +1 more source