Results 111 to 120 of about 1,333,578 (308)

Biomechanics of vascular mechanosensation and remodeling

Molecular Biology of the Cell, 2016
Flowing blood exerts a frictional force, fluid shear stress (FSS), on the endothelial cells that line the blood and lymphatic vessels. The magnitude, pulsatility, and directional characteristics of FSS are constantly sensed by the endothelium. Sustained increases or decreases in FSS induce vessel remodeling to maintain proper perfusion of tissue.
Baeyens, Nicolas, Schwartz, Martin A
openaire   +4 more sources

Pressure‐Assisted Drug Delivery Using High‐Pressure Balloon Platform Improves Vascular Drug Penetration and Anti‐Restenotic Effects

Advanced Healthcare Materials, EarlyView.
A dual‐layer high‐pressure drug‐coated balloon (HP@DCB) increased balloon‐wall contact and promoted deeper paclitaxel (PTX) penetration than a conventional noncompliant DCB. In in vivo study, HP@DCB treatment improved luminal patency and reduced neointimal hyperplasia, supporting pressure‐assisted drug delivery as a promising strategy for enhancing the
Seung Jin Eo, So Yun Lim, Dong‐Sung Won, Ji Won Kim, Yubeen Park, Song Hee Kim, Hyemin Lee, Jung‐Min Ahn, Jun‐Kyu Park, Do‐Yoon Kang, Jung‐Hoon Park   +10 more
wiley   +1 more source

Endothelial progenitor cells in age-related vascular remodeling

, 2018
Accumulating evidence has demonstrated that endothelial progenitor cells (EPCs) could facilitate the reendothelialization of injured arteries by replacing the dysfunctional endothelial cells, thereby suppressing the formation of neointima.
Xing-Xiang Wang, Wei Mao, Yan-Yun Pan, Jin-Xiu Yang, Yuan-Gang Qiu   +4 more
core   +1 more source

Seipin‐Mediated Lipid Droplet Formation in Cardiomyocytes Ameliorates Cardiac Ischemia/Reperfusion Injury

Advanced Science
Cardiac ischemia/reperfusion (I/R) injury is an important therapeutic target for ischemic heart disease. Lipid droplets (LDs) are the key organelles involved in lipid metabolism.
Changyun Liu, Junxia Zhang, Yusi Chen, Geng Shen, Yufei Han, Zihao Zhou, Jinxuan Chen, Xuya Kang, Huilin Qu, Jiaxin Duanmu, Haibao Shang, Yingjia Li, Wei Huang, Yan Zhang   +13 more
doaj   +1 more source

Androgen-Induced Lactic Acid Accumulation Contributes to the Apoptosis of Ovarian Granulosa Cells in Polycystic Ovary Syndrome Mice

Antioxidants
Background: Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility. The apoptosis of granulosa cells (GCs) is strongly associated with the impaired follicular development in PCOS.
Bining Zhao, Liting Fan, Mengfei Liu, Haowen Wu, Youyou Zhang, Qiyang Shen, Jihong Kang   +6 more
doaj   +1 more source

A Triboelectric‐Hydrogel System for Mechano‐Metabolic Re‐Coupling in Skin Expansion: Recharging From Energy Crisis

Advanced Healthcare Materials, EarlyView.
Progressive skin expansion creates an energy crisis that compromises regenerative capacity. A self‐powered triboelectric‐hydrogel system (TP‐PAM/G) re‐couples mechanical loading with cellular metabolism by combining motion‐generated electrical stimulation and stress redistribution.
Xing Huang, Yuduo Zhu, Fei Liu, Lei Liu, Shengzhou Shan, Yujui Lai, Peiyi Li, Xiao Zhang, Xusong Luo, Mengling Chang, He Xu   +10 more
wiley   +1 more source

Fenofibrate attenuates hyperhomocysteinemia-potentiated thrombosis by restoring platelet fatty acid β-oxidation

Redox Biology
Hyperhomocysteinemia (HHcy) is an independent risk factor for thrombotic cardiovascular events. We previously demonstrated that homocysteine (Hcy) amplifies platelet activation by promoting membrane remodeling and enhancing signaling through surface ...
Lulu Han, Xing Du, Yu Yan, Linqi Zhang, Juan Feng, Xian Wang, Xingzhong Zhang   +6 more
doaj   +1 more source

Mechanisms of Vascular Remodeling in Hypertension

American Journal of Hypertension, 2020
Abstract Hypertension is both a cause and a consequence of central artery stiffening, which in turn is an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such stiffening results from a remodeling of the arterial wall that is driven by mechanical stimuli and mediated by inflammatory signals, which ...
openaire   +3 more sources

Hybrid Biofabrication of a Hierarchically Organized Periosteum‐Inspired In Vitro Platform

Advanced Healthcare Materials, EarlyView.
A hybrid biofabrication strategy integrates melt electrowriting with extrusion‐based 3D bioprinting to create a hierarchically organized periosteum‐inspired in vitro platform. Spatially defined osteogenic, fibrous, and endothelial cell‐containing compartments support long‐term culture, osteogenic maturation, and CD31+ endothelial cell organization ...
Yakui Liu, Xinggui Tian, Anne Bernhardt, Anja Lode, Max von Witzleben, Ege Kirbas, Stefan Zwingenberger, Michael Gelinsky   +7 more
wiley   +1 more source

Healthy diet attenuates the cardiovascular risk associated with elevated monocytes: a prospective cohort study

Frontiers in Nutrition
BackgroundElevated monocyte counts predict cardiovascular disease (CVD) risk, but whether this inflammatory risk is modifiable by dietary patterns remains unknown.
Xueguang Lin, Xueguang Lin, Shishuai Xie, Shishuai Xie, Qi Sun, Ying Deng, Ying Deng, Jingdong Tang, Jingdong Tang, Hui Zhang, Bo Yu, Shuai Jiang, Shuai Jiang   +12 more
doaj   +1 more source