Results 131 to 140 of about 1,333,578 (308)

Enhancing SDT Efficacy of Doxorubicin‐Loaded Sonosensitizer Micelles to Overcome Resistance of Cancer Therapy by Optimizing Acoustic Parameters

Aggregate
Tumor drug resistance has been reported to be associated with drug efflux in tumor cells. Recently, a noninvasive and safe mechanism, sonodynamic therapy (SDT), has been proposed to be an oxidative stress strategy to potentially overcome drug efflux, but
Zhuoran Gong, Deshang Hou, Yunxue Xu, Mengxuan Wang, Shiyin Lin, Yingjuan Zheng, Zhifei Dai   +6 more
doaj   +1 more source

Baseline low-grade systemic inflammation and risk of hospitalized venous thromboembolism: A UK Biobank cohort study

Thrombosis Update
Background: Venous thromboembolism (VTE) is a major vascular disease associated with substantial morbidity and mortality worldwide. Chronic low-grade systemic inflammation has been implicated in thrombus formation, yet its long-term association with ...
Yi-Jie Lu, Shi-Yu Tang, Meng Hao, Shu-Ya Tang, Hui Zhang, Serick Duysenbi, Najiahai Jinsihan, Bo Yu, Jing-Dong Tang, Shuai Jiang, Bing-bing Pu, Ying Deng   +11 more
doaj   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Class IA Phosphatidylinositol 3-Kinase Isoform p110 alpha Mediates Vascular Remodeling

, 2015
Objective-Neointima formation after vascular injury remains a significant problem in clinical cardiology, and current preventive strategies are suboptimal.
Vantler, Marius, Scherner, Maximilian, Blaschke, Florian, Leppaenen, Olli,, ten Freyhaus, Henrik, Baldus, Stephan, Sterner-Kock, Anja, Mustafov, Lenard, Jesus, Joana, Chen, Xin, Zierden, Mario, Rosenkranz, Stephan, Berghausen, Eva Maria, Gerhardt, Maximilian, Kramer, Tilmann, Zhao, Jean J.   +15 more
core   +1 more source

Protocol to analyze immune cells in the tumor microenvironment by transcriptome using machine learning

STAR Protocols
Summary: Immunotherapy is a promising strategy to treat cancer. Here, we present a protocol for analyzing the transcriptome-based phenotypic alterations and immune cell infiltration in the tumor microenvironment.
Yunxi Liao, Ziyan Rao, Shaodong Huang, Dongyu Zhao   +3 more
doaj   +1 more source

Programmable Microgel Degradation in Dynamic Granular Hydrogels Guides Extracellular Matrix Assembly During Tissue Repair

Advanced Materials, EarlyView.
This study reports on the chemical modification of hyaluronic acid to create hydrogels with hydrolytic degradability ranging from 2–28 days. Granular hydrogels that undergo timed degradation to increase porosity enhance cell invasion and provisional ECM remodeling in a muscle injury model, leading to reduced fibrosis and improved regeneration ...
Zhiyuan Chen, Tuba Marjan, Xinyue Lu, Nicole E. Mertens, Keira Vesy, Dean E. Stornello, James F. Markworth, Taimoor H. Qazi   +7 more
wiley   +1 more source

Deficiency of Leucine‐Rich Repeat Containing G Protein‐Coupled Receptor 4 in Pancreas Reduces β Cell Mass

Advanced Science
Although leucine‐rich repeat‐containing G protein‐coupled receptor 4 (LGR4) is abundantly expressed in the pancreas, it is currently unknown whether LGR4 impacts pancreatic endocrine cells.
Chao Luo, Yifan Feng, Jiajie Min, Yan Zhao, Ziming Zhu, Lijun Sun, Hao Yin, Yue Yin, Weizhen Zhang   +8 more
doaj   +1 more source

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

Advanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren, Alex Wu, Lucas Ramirez, Yaqing Huang, Connor Amelung, Sophia Saxonhouse, Sharon Gerecht   +6 more
wiley   +1 more source

ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery

, 2017
Key Points ADAMTS13 controls key steps of vascular remodeling during stroke recovery. Recombinant ADAMTS13 enhances ischemic neovascularization and vascular repair.
Ping Cai, Haochen Xu, Lu Lu, Lixiang Wei, Xing Yang, Haiyu Luo, Yuanbo Zhu, Bing-Qiao Zhao, Xiaofei Bai, Yongliang Cao, Lijing Kang, Wenying Fan, Ximin Zhu   +12 more
core   +1 more source

Imaging-Based Spatial Transcriptomics: Data Interpretation Methods and Biomedical Applications

Biology
Imaging-based spatial transcriptomics has advanced from low-plex single-molecule fluorescence in situ hybridization to a diverse set of highly multiplexed platforms, with recent multimodal and pathology-compatible capabilities.
Wenhao Li, Yuan Zhou
doaj   +1 more source