, 2009 The endothelium controls vascular tone not only by releasing NO and prostacyclin, but also by other pathways causing hyperpolarization of the underlying smooth muscle cells.
Félétou, M, VanHoutte, PM
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Enhanced expression of fibroblast growth factors and receptor FGFR-1 during vascular remodeling in chronic obstructive pulmonary disease [PDF]
, 2002 Important characteristics of chronic obstructive pulmonary disease (COPD) include airway and vascular remodeling, the molecular mechanisms of which are poorly understood.
Boer, W.I. (Pim) de +7 more
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Vascular smooth muscle cell differentiation – 2010 [PDF]
Journal of Biomedical Research, 2010 Vascular smooth muscle cells have attracted considerable interest as a model for a flexible program of gene expression. This cell type arises throughout the embryo body plan via poorly understood signaling cascades that direct the expression of transcription factors and microRNAs which, in turn, orchestrate the activation of contractile genes ...
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Smooth muscle cells and vascular diseases [PDF]
Cardiovascular Research, 2012 Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, and, due to their myosin/actin interactions, they are also responsible for arterial contractile tonus and regulating blood pressure and flow in relation to specific metabolic demands.
Jean-Baptiste, Michel +2 more
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MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.
PLoS Genetics, 2019 As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston +3 more
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Maintenance of GLUT4 expression in smooth muscle prevents hypertension‐induced changes in vascular reactivity [PDF]
, 2015 Previous studies have shown that expression of GLUT4 is decreased in arterial smooth muscle of hypertensive rats and mice and that total body overexpression of GLUT4 in mice prevents enhanced arterial reactivity in hypertension.
Atkins, Kevin B. +5 more
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A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-kB [PDF]
, 2015 Vascular calcifications bear the risk for cardiovascular complications and have a high prevalence among patients with chronic kidney disease. Central mediators of vascular calcifications are vascular smooth muscle cells (VSMC).
Freise, Christian +2 more
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Vascular smooth muscle caldesmon.
Journal of Biological Chemistry, 1986 Caldesmon, a major actin- and calmodulin-binding protein, has been identified in diverse bovine tissues, including smooth and striated muscles and various nonmuscle tissues, by denaturing polyacrylamide gel electrophoresis of tissue homogenates and immunoblotting using rabbit anti-chicken gizzard caldesmon.
T, Clark +4 more
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SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
Nature Communications, 2017 The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 ...
Ning Xie +14 more
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Spontaneous contractile dynamics of the vascular smooth muscle of the external carotid artery
Medisan, 2021 Introduction: The external carotid is a muscle artery irrigating all components of the masticatory system, so that the regulation of the contractile dynamics of its vascular smooth muscle is important.
Oscar Rodríguez Reyes +3 more
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