Journal of Pharmacological Sciences, 2004 A serine proteinase with kallikrein-like activity (LV-Ka) has been purified to homogeneity from bushmaster snake (Lachesis muta muta) venom. Physicochemical studies indicated that LV-Ka is a single chain glycoprotein with a molecular mass (Mr) of 33 kDa ...
Maria L.D. Weinberg +6 more
doaj
Frontiers in Physiology, 2017 There are two primary components that produce pulmonary arterial hypertension (PAH); aberrant structural changes (smooth muscle cell proliferation, smooth muscle cell hypertrophy, and the deposition of matrix proteins within the media of pulmonary ...
Melissa A. Lyle +2 more
doaj +1 more source
Arteriosclerosis, Thrombosis and Vascular Biology, 2016 Decades of work have shown that vascular smooth muscle cell (SMC) phenotypes are controlled by cues received from the local environment.1–3 When nestled into a cage of cross-linked collagen and elastin of its own making,4 medial SMCs exhibit a fully ...
M. Majesky
semanticscholar +1 more source
Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.
Comprehensive Physiology, 2017 Vascular tone of resistance arteries and arterioles determines peripheral vascular resistance, contributing to the regulation of blood pressure and blood flow to, and within the body's tissues and organs.
N. Tykocki, E. Boerman, W. Jackson
semanticscholar +1 more source
Smad7 Misexpression during Embryonic Angiogenesis Causes Vascular Dilation and Malformations Independently of Vascular Smooth Muscle Cell Function [PDF]
, 2001 Numerous in vitro and in vivo studies implicate transforming growth factor-β (TGFβ) superfamily signaling in vascular development and maintenance. Mice and humans with mutations in TGFβ superfamily signaling pathway genes exhibit a range of vascular ...
Laufer, Ed, Vargesson, Neil
core +1 more source
SRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway
Nature Communications, 2017 The hyperproliferation of vascular smooth muscle cells underlies many vascular diseases. Here Xieet al. show that the splicing factor SRSF1 is an endogenous stimulator of human and mouse aortic smooth muscle cell proliferation via the Δ133p53/EGR1/KLF5 ...
Ning Xie +14 more
doaj +1 more source
Patient-specific predictions of aneurysm growth and remodeling in the ascending thoracic aorta using the homogenized constrained mixture model [PDF]
Biomechanics and Modeling in Mechanobiology, Springer Verlag,
2019, 18 (6), pp.1895-1913, 2019 In its permanent quest of mechanobiological homeostasis, our vascula-ture significantly adapts across multiple length and time scales in various physiological and pathological conditions. Computational modeling of vascular growth and remodeling (G\&R) has significantly improved our insights of the mechanobio-logical processes of diseases such as ...
arxiv +1 more source
Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury [PDF]
, 2015 Producción CientíficaObjective: Actin dynamics in vascular smooth muscle is known to regulate contractile differentiation and may play a role in the pathogenesis of vascular disease. However, the list of genes regulated by actin polymerization in smooth
Albinsson, Sebastian +13 more
core +1 more source
MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling.
PLoS Genetics, 2019 As small regulatory transcripts, microRNAs (miRs) act as genetic 'fine tuners' of posttranscriptional events, and as genetic switches to promote phenotypic switching. The miR miR26a targets the BMP signalling effector, smad1.
Charlene Watterston +3 more
doaj +1 more source
Endothelial and smooth muscle cell interactions with a PCL-PU composite vascular scaffold with potential for bioactive release [PDF]
, 2006 Paper discussing endothelial and smooth muscle cell interactions with a PCL-PU composite vascular scaffold with potential for bioactive ...
Black, Richard +2 more
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