Results 221 to 230 of about 385,157 (356)

Effects and mechanisms of trifolin on attenuating hypertension-induced vascular smooth muscle cell proliferation and collagen deposition in vivo and in vitro. [PDF]

Sci Rep
Shen A, Wu M, Guo Z, Ali F, Wu J, Chen H, Cheng Y, Lian D, Peng J, Yu M, Chen K.   +10 more
europepmc   +1 more source

Vasopressin‐stimulated [³H]‐inositol phosphate and [³H]‐phosphatidylbutanol accumulation in A10 vascular smooth muscle cells [PDF]

, 1992
Robin Plevin, Allison Stewart, Andrew Paul, Michael J.O. Wakelam   +3 more
openalex   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Lactate Dehydrogenase A Crotonylation and Mono-Ubiquitination Maintains Vascular Smooth Muscle Cell Growth and Migration and Promotes Neointima Hyperplasia. [PDF]

J Am Heart Assoc
Chen ZH, Cao SH, Ren ZY, Zhang T, Jiang HM, Hu ZK, Dong LH.   +6 more
europepmc   +1 more source

Thrombin signal transduction mechanisms in rat vascular smooth muscle cells. Calcium and protein kinase C-dependent and -independent pathways.

, 1990
Bradford C. Berk, Mark B. Taubman, Edward J. Cragoe, John W. Fenton, Kathy K. Griendling   +4 more
openalex   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

miR-29a-3p/<i>Vegfa</i> axis modulates high phosphate-induced vascular smooth muscle cell calcification. [PDF]

Ren Fail
Fu C, Liang Q, Ma L, Liu W, Guo W, Wang G.   +5 more
europepmc   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

The Calcimimetic R568 Reduces Vascular Smooth Muscle Cell Calcification in Vitro Via ERK 1/2 Phosphorylation. [PDF]

Int J Nephrol
Engeßer J, Albert PG, Scheuch M, Loth N, Stracke S.   +4 more
europepmc   +1 more source

Vascular aldosterone. Biosynthesis and a link to angiotensin II-induced hypertrophy of vascular smooth muscle cells.

, 1994
Hiromitsu Hatakeyama, Isamu Miyamori, Tomoyuki Fujita, Yoshiyu Takeda, Ryosuke Takeda, Hiroshi Yamamoto   +5 more
openalex   +1 more source