Results 291 to 300 of about 385,157 (356)

Regulated vascular smooth muscle cell death in vascular diseases. [PDF]

Cell Prolif
Yin Z, Zhang J, Shen Z, Qin JJ, Wan J, Wang M.   +5 more
europepmc   +1 more source

Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis

Advanced Science, EarlyView.
Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan, Hai Tang, Lanlan Wang, Qingfeng Bai, Yi Chen, Runfeng Cao, Weikang Lin, Lei Wang, Yulong Hu, Guofang Zhao, Minglei Yang, Weiyan Sun, Kun Zhang, Dawei Li, Chang Chen   +14 more
wiley   +1 more source

TWEAK/Fn14 axis may promote vascular smooth muscle cell senescence via p38 signaling pathway: preliminary evidence. [PDF]

Future Sci OA
Wei C, Liu X, Miao Z, Zhang H, Wang Y, Qi G.   +5 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Author Correction: Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence. [PDF]

Nat Commun
Sun DY, Wu WB, Wu JJ, Shi Y, Xu JJ, Ouyang SX, Chi C, Shi Y, Ji QX, Miao JH, Fu JT, Tong J, Zhang PP, Zhang JB, Li ZY, Qu LF, Shen FM, Li DJ, Wang P.   +18 more
europepmc   +1 more source

LncRNA Foxo6os as a Novel “ Scaffold” Mediates MYBPC3 in Combating Pathological Cardiac Hypertrophy and Heart Failure

Advanced Science, EarlyView.
Schematic overview showing that forkhead box O6, opposite strand (Foxo6os) acts as a “scaffold”, directly binding myosin‐binding protein‐C (MYBPC3) and recruiting protein kinase C (PKC‐α) to mediate site‐specific phosphorylation of MYBPC3. This post‐translational modification supports cardiac contraction by regulating L‐type Ca2+ channels, especially ...
Jie Sheng, Qin Lin, Yizhuo Sun, Yilei Meng, Sangyu Hu, Huaming Cao, Fang Lin, Yuping Zhu, Luying Peng, Li Li   +9 more
wiley   +1 more source

Inositol 1,4,5-Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice. [PDF]

J Am Heart Assoc
Huang F, Zhang F, Huang L, Zhu X, Huang C, Li N, Da Q, Huang Y, Yang H, Wang H, Zhao L, Lin Q, Chen Z, Xu J, Liu J, Ren M, Wang Y, Han Z, Ouyang K.   +18 more
europepmc   +1 more source

FOXM1 Protects Against Myocardial Ischemia‐Reperfusion Injury in Rodent and Porcine Models by Suppressing MKRN1‐Dependent LKB1 Ubiquitination

Advanced Science, EarlyView.
FOXM1 maintains mitochondrial bioenergetic function by inhibiting MKRN1‐mediated ubiquitination of LKB1 in cardiomyocytes. Loss of FOXM1 in cardiomyocytes results in upregulation of MKRN1, which enhances LKB1 ubiquitination and disrupts AMPK signaling and energy metabolism pathways. Conversely, FOXM1 overexpression preserves mitochondrial bioenergetics
Shuai Song, Xiaokai Zhang, Zihang Huang, Zhiqiang Pei, Linqi Zeng, Fengze Cai, Tongyao Wang, Mohan Li, Chenyan Liu, Yining Song, Jiahao Guo, Hao Lu, Xinyu Weng, Li Shen, Xiaochun Zhang, Xingxing Cai, Aijun Sun, Junbo Ge   +17 more
wiley   +1 more source

Gut microbiota-derived Metabolite, Shikimic Acid, inhibits vascular smooth muscle cell proliferation and migration. [PDF]

Biochem Pharmacol
Kumariya S, Grano de Oro A, Nestor-Kalinoski AL, Joe B, Osman I.   +4 more
europepmc   +1 more source

Graphene‐Based Oscillators for Biomimetic Neuro‐Interfaces

Advanced Electronic Materials, EarlyView.
Graphene oxide membranes combined with polyelectrolytes form ionic transistors that generate oscillatory ion currents, mimicking neuronal signaling. These low‐voltage devices synchronize Ca2+ flux, modulate vascular smooth muscle contraction, and integrate into multivibrator circuits, offering a bioinspired platform for neuromorphic electronics and ...
Konstantin G. Nikolaev, Sergey Grebenchuk, Zhao Jinpei, Kou Yang, Yixin Zhang, Ong Mei Shan, Vitaly Sorokin, Siyu Chen, Qian Wang, Jia Hui Bong, Kostya S. Novoselov, Daria V. Andreeva   +11 more
wiley   +1 more source