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MicroRNA and Vascular Smooth Muscle Cells
2011Vascular smooth muscle cells (VSMCs) exhibit extraordinary plasticity during postnatal development. Vascular injury initiates VSMC phenotypic switch from the contractile to proliferative phenotype, which plays a central role in vascular lesion formation and diverse vascular diseases.
Y. Eugene Chen +2 more
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2002
Smooth muscle is present in one form or another in most organs, and its contractile activity is vital for normal functioning of the body. To be able to perform the multitude of tasks required of the organs, smooth muscle cells vary widely in their patterns of activity.
Campbell, G. R. +2 more
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Smooth muscle is present in one form or another in most organs, and its contractile activity is vital for normal functioning of the body. To be able to perform the multitude of tasks required of the organs, smooth muscle cells vary widely in their patterns of activity.
Campbell, G. R. +2 more
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Production of Endothelin by Vascular Smooth Muscle Cells
Journal of Cardiovascular Pharmacology, 1991Endothelin (ET) production by cultured vascular smooth muscle cells isolated from rat and rabbit aortae was measured by a specific radioimmunoassay. Vascular smooth muscle cells released ET at a rate of 0.6 (range of 0.1-1) fmol/10(5) cells/24 h compared to 45 (range of 10-80) fmol/10(5) cells/h for endothelial cells.
KANSE SM +6 more
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Pathophysiological Role of the Vascular Smooth Muscle Cell
Journal of Cardiovascular Pharmacology, 1990The vascular smooth muscle cell of the arterial media plays a predominant role in functional and structural alterations of the arterial wall in pathophysiological processes such as arterial hypertension, atheroma, or normal aging. The observed alterations are related to the three activities of the vascular smooth muscle cell, namely contractility ...
Michel Jb +5 more
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Chapter 7 Vascular Smooth Muscle Cell Cultures
1997Publisher Summary Vascular smooth muscle cells (VSMCs) are the predominant cell type in blood vessels of the arterial tree. They are responsible for maintaining vascular tone in response to various hormonal and hemodynamic stimuli and they are the major cell type involved in the process of vascular repair, growth, and response to injury.
Michael T. Crow +4 more
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Lysolecithin actions on vascular smooth muscle cells
Biochemical and Biophysical Research Communications, 1992Oxidation of low density lipoprotein increases its atherogenic potential. During oxidation there is an extensive conversion of lecithin to lysolecithin. In rat aortic smooth muscle cells, 2-25 micrograms/ml lysolecithin elevated cytosolic calcium concentration up to 560%.
Rudolf Locher +4 more
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Vascular smooth muscle cells and calcification in atherosclerosis
American Heart Journal, 2004Vascular calcification is a prominent feature of atherosclerosis but the mechanisms underlying vascular calcification are still obscure. Since bone-associated proteins such as osteonectin, osteocalcin, and matrix Gla protein have been detected in calcified vascular tissues, calcification has been considered to be an organized, regulated process similar
Astrid Trion, Arnoud van der Laarse
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The roles of autophagy in vascular smooth muscle cells
International Journal of Cardiology, 2016Autophagy, which is an evolutionarily conserved mechanism and links to several cellular pathways, impacts vascular smooth muscle cells (VSMCs) survival and function. Activation of autophagy by intercellular and/or extracellular stimuli has protective effects on VSMCs against cell death, while on the contrary, overloading autophagy has been recognized ...
Xinqun Hu +5 more
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Endothelin degradation by vascular smooth muscle cells
Regulatory Peptides, 1996The mechanism(s) of degradation of the potent vasoconstrictor endothelin-1 (ET-1) by rat vascular smooth muscle A-10 cells, which possess the ETA receptor subtype, was investigated by incubating [125I]ET-1 (0.1 nM) with cells for 0-4 h at 37 degrees C in the presence and absence of lysosomal enzyme inhibitors, NH4Cl and chloroquine, and a neutral ...
Adviye Ergul +4 more
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Thrombin and Proliferation of Vascular Smooth Muscle Cells
Circulation Research, 1995Thrombin is a well-established promoter of vascular SMC proliferation in vitro. A similar role has been suggested but not yet proven in vivo. The effect is mediated via selective receptors expressed on vascular SMCs in vitro. Activation of the thrombin receptor leads to a number of intracellular signaling events as well as to stimulation of endogenous ...
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