Results 121 to 130 of about 397,979 (354)
Engineered 3D‐Cad/IL6‐MSC, developed through synergistic hE/N‐cad‐Fc and IL‐6 preconditioning, show remarkable therapeutic potential for systemic sclerosis. These engineered MSC aggregates reduce pathogenic inflammatory cell infiltration and restore immune balance among CD4+ T‐cell populations, offering a promising approach to optimize MSC based ...
Yue Zhang+11 more
wiley +1 more source
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex+4 more
wiley +1 more source
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz+2 more
wiley +1 more source
Pulmonary hypertension is a major cardiovascular disease characterized by the persistent elevation of pulmonary artery pressure, leading to vascular remodeling, fibrosis, and endothelial dysfunction.
Yimo Huang+4 more
doaj +1 more source
Vascular smooth muscle cells (VSMCs) are primarily responsible for vasoconstriction and the regulation of blood pressure1. Pyroptosis, a particular form of regulated cell death, is involved in multiple vascular injuries, including hypertensive vascular ...
Zimin Fang+9 more
doaj
Biphasic Granular Bioinks for Biofabrication of High Cell Density Constructs for Dermal Regeneration
This study introduces a biphasic granular bioink (µInk) that enables 3D bioprinting of high cell density constructs for dermal regeneration. The bioink promotes cell proliferation, ECM deposition, and neovascularization, leading to tissue integration and reduced scar formation in vivo.
Rozalin Shamasha+16 more
wiley +1 more source
Background The fusiform aneurysm is a nonsaccular dilatation affecting the entire vessel wall over a short distance. Although PDGFRB somatic variants have been identified in fusiform intracranial aneurysms, the molecular and cellular mechanisms driving ...
Li Hao+12 more
doaj +1 more source
Brain natriuretic peptide interacts with atrial natriuretic peptide receptor in cultured rat vascular smooth muscle cells [PDF]
Yukio Hirata+5 more
openalex +1 more source
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee+9 more
wiley +1 more source
Regulation and Roles of Urocortins in the Vascular System
Urocortins (Ucns) are members of the corticotropin-releasing factor (CRF) family of peptides. Ucns would have potent effects on the cardiovascular system via the CRF receptor type 2 (CRF2 receptor).
Kazunori Kageyama+3 more
doaj +1 more source