Microphysiological Systems of Lymphatics and Immune Organs
Advanced Healthcare Materials, EarlyView.This review surveys recent progress in engineering lymphatic microenvironments and immune organoids within microphysiological systems, emphasizing innovative strategies to recreate the biochemical and biophysical complexity of native lymphatic tissues.
Ishita Jain +2 more
wiley +1 more source
Vascular smooth muscle cell apoptosis in atherosclerosis [PDF]
International Journal of Experimental Pathology, 1999 Cell death has long been recognized within the vessel wall, in particular, in disease states such as atherosclerosis. The use of the term ‘necrotic core’ for the central lipid core of advanced lesions emphasizes this. Indeed there is obvious cell fragmentation and cell debris in areas of plaques, particularly the lipid core (Mitchinson et al.
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Cytoglobin Expression Is Induced in Vascular Smooth Muscle Cells Through Endothelial Cell-Derived Notch Signaling: Implications of a Protective Role in Blood Vessel Function [PDF]
, 2017 Communication between endothelial cells and smooth muscle cells is required for normal blood vessel formation and function. My research focuses on understanding the molecular signaling pathways that govern cell-cell communication and maintain vascular ...
Dammeyer, Kristen
core
Perivascular adipose tissue inflammation in vascular disease [PDF]
, 2017 Perivascular adipose tissue (PVAT) plays a critical role in the pathogenesis of cardiovascular disease. In vascular pathologies, perivascular adipose tissue increases in volume and becomes dysfunctional, with altered cellular composition and molecular ...
Guzik, Tomasz J., Nosalski, Ryszard
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Bioengineered Lymphatic Vessels in Synthetic Matrices to Study Breast Cancer Cell Functions
Advanced Healthcare Materials, EarlyView.Lymphatic vessels are involved in cancer metastasis. To study the interplay between metastasizing cancer cells and lymphatic vessels under highly reproducible conditions, advanced in vitro models are required. In this work, 3D lymphatic networks are formed in biomimetic hydrogels and their interactions with invasive and non‐invasive cancer cell‐lines ...
Rodi Odabasi +7 more
wiley +1 more source
A Lindera obtusiloba Extract Blocks Calcium-/Phosphate-Induced Transdifferentiation and Calcification of Vascular Smooth Muscle Cells and Interferes with Matrix Metalloproteinase-2 and Metalloproteinase-9 and NF-kB [PDF]
, 2015 Vascular calcifications bear the risk for cardiovascular complications and have a high prevalence among patients with chronic kidney disease. Central mediators of vascular calcifications are vascular smooth muscle cells (VSMC).
Freise, Christian +2 more
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Advanced Healthcare Materials, EarlyView.We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin +18 more
wiley +1 more source
Defining the Role of Notch Signaling in Vascular Smooth Muscle Cell Differentiation [PDF]
, 2014 accepted into the Wilbert C. Jordan Student Research Forum hosted by the Student National Medical Association at the 50th Annual Medical Education ConferenceComplications resulting from vascular disease such as atherosclerosis are a major health concern ...
Jackson, Kamari
core
Advanced Healthcare Materials, EarlyView.This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu +10 more
wiley +1 more source
AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation [PDF]
, 2010 Junyu Ning, David R. Clemmons
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