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Chapter 7 Vascular Smooth Muscle Cell Cultures
1997Publisher Summary Vascular smooth muscle cells (VSMCs) are the predominant cell type in blood vessels of the arterial tree. They are responsible for maintaining vascular tone in response to various hormonal and hemodynamic stimuli and they are the major cell type involved in the process of vascular repair, growth, and response to injury.
Michael T. Crow +4 more
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Lysolecithin actions on vascular smooth muscle cells
Biochemical and Biophysical Research Communications, 1992Oxidation of low density lipoprotein increases its atherogenic potential. During oxidation there is an extensive conversion of lecithin to lysolecithin. In rat aortic smooth muscle cells, 2-25 micrograms/ml lysolecithin elevated cytosolic calcium concentration up to 560%.
Rudolf Locher +4 more
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Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells.
Circulation Research, 1995Multiple growth factors can stimulate quiescent vascular smooth muscle cells to exit from G0 and reenter the cell cycle. The macrolide antibiotic rapamycin, bound to its cytosolic receptor FKBP, is an immunosuppressant and a potent inhibitor of cellular ...
S. Marx +3 more
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Vascular smooth muscle cells and calcification in atherosclerosis
American Heart Journal, 2004Vascular calcification is a prominent feature of atherosclerosis but the mechanisms underlying vascular calcification are still obscure. Since bone-associated proteins such as osteonectin, osteocalcin, and matrix Gla protein have been detected in calcified vascular tissues, calcification has been considered to be an organized, regulated process similar
Astrid Trion, Arnoud van der Laarse
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The roles of autophagy in vascular smooth muscle cells
International Journal of Cardiology, 2016Autophagy, which is an evolutionarily conserved mechanism and links to several cellular pathways, impacts vascular smooth muscle cells (VSMCs) survival and function. Activation of autophagy by intercellular and/or extracellular stimuli has protective effects on VSMCs against cell death, while on the contrary, overloading autophagy has been recognized ...
Xinqun Hu +5 more
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Sodium Cotransport in Vascular Smooth Muscle Cells
Journal of Vascular Research, 1991Vascular smooth muscle cells possess a number of Na cotransport systems. Three of these cotransport systems, Na/Ca exchange, Na/H exchange and Na-K-Cl cotransport, have been the subject of an increasing number of investigations to determine the respective roles of these transporters in vascular smooth muscle cell function.
N. E. Owen, Martha E O'Donnell
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Endothelin degradation by vascular smooth muscle cells
Regulatory Peptides, 1996The mechanism(s) of degradation of the potent vasoconstrictor endothelin-1 (ET-1) by rat vascular smooth muscle A-10 cells, which possess the ETA receptor subtype, was investigated by incubating [125I]ET-1 (0.1 nM) with cells for 0-4 h at 37 degrees C in the presence and absence of lysosomal enzyme inhibitors, NH4Cl and chloroquine, and a neutral ...
Adviye Ergul +4 more
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Thrombin and Proliferation of Vascular Smooth Muscle Cells
Circulation Research, 1995Thrombin is a well-established promoter of vascular SMC proliferation in vitro. A similar role has been suggested but not yet proven in vivo. The effect is mediated via selective receptors expressed on vascular SMCs in vitro. Activation of the thrombin receptor leads to a number of intracellular signaling events as well as to stimulation of endogenous ...
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Molecular regulation of vascular smooth muscle cell differentiation in development and disease.
Physiological Reviews, 2004The focus of this review is to provide an overview of the current state of knowledge of molecular mechanisms/processes that control differentiation of vascular smooth muscle cells (SMC) during normal development and maturation of the vasculature, as well
G. Owens, Meena S. Kumar, B. Wamhoff
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Directed Movement of Vascular Smooth Muscle Cells on Gradient-Compliant Hydrogelsâ€
, 2003Current solutions in the treatment of cardiovascular disease include angioplasty and the insertion of stents, but a large number of these cases result in restenosis.
J. Wong +3 more
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