Results 191 to 200 of about 1,799,199 (341)

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Altered cardiac and vascular stiffness in pregnancy after a hypertensive pregnancy. [PDF]

J Hum Hypertens, 2023
Castleman JS, Shantsila A, Brown RA, Shantsila E, Lip GYH.   +4 more
europepmc   +1 more source

A Synovium‐on‐Chip Platform to Study Multicellular Interactions in Arthritis

Advanced Healthcare Materials, EarlyView.
The Synovium‐on‐Chip comprises a thin microporous PDMS membrane to support co‐culture of fibroblast‐like synoviocytes (FLS), THP‐1‐derived macrophages, and endothelial cells, enabling real‐time analysis of synovial‐vascular interactions. FLS migration through the pores drives endothelial remodeling, while TNF‐α stimulation induces robust inflammatory ...
Laurens R. Spoelstra, Fleur R. Semmekrot, Nuno Araújo‐Gomes, Daniël Wijnperle, Monique M. A. Helsen, Martijn H.J. Van Den Bosch, Loes. I. Segerink, Séverine Le Gac, Marcel Karperien   +8 more
wiley   +1 more source

Arterial Stiffness and Aortic Aneurysmal Disease – A Narrative Review

Vascular Health and Risk Management
Konstantinos G Moulakakis,1,* Christos F Pitros,1,* Ioannis T Theodosopoulos,2 Spyridon N Mylonas,3 John D Kakisis,2 Christos Manopoulos,4 Nikolaos PE Kadoglou5 1Department of Vascular Surgery, Patras University Hospital, University of Patras ...
Moulakakis KG, Pitros CF, Theodosopoulos IT, Mylonas SN, Kakisis JD, Manopoulos C, Kadoglou NPE   +6 more
doaj  

Utility of estimated pulse wave velocity for assessing vascular stiffness: comparison of methods. [PDF]

Elife, 2022
Möstl S, Hoffmann F, Hönemann JN, Alvero-Cruz JR, Rittweger J, Tank J, Jordan J.   +6 more
europepmc   +1 more source

The role of glycosaminoglycans in vascular stiffness and non-osmotic sodium storage

, 2018
Kathleen Connolly
openalex   +1 more source

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

Vascular Grafts with Tailored Stiffness and a Ligand Environment via Multiarmed Polymer Sheath for Expeditious Regeneration

, 2020
Monica Iglesias-Echevarria, Richard Johnson, Michael Rafuse, Yonghui Ding, Wei Tan   +4 more
openalex   +2 more sources

From short‐term blood pressure variability to atherosclerosis: Relative roles of vascular stiffness and endothelial dysfunction [PDF]

, 2020
Alfonso Tatasciore, Marta Di Nicola, Roberto Tommasi, Francesco Santarelli, Carlo Palombo, Gianfranco Parati, Raffaele De Caterina   +6 more
openalex   +1 more source

3D‐Printed Titanium Implants with Bioactive Peptide‐Polysaccharide Scaffolds for Personalized Bone Reconstruction

Advanced Healthcare Materials, EarlyView.
Porous 3D‐printed titanium implants are made bioactive by integration with a supramolecular peptide‐hyaluronic acid nanofibrillar scaffold, without the addition of exogenous cells or growth factors. Uniform filling of the implant architecture promotes vascularized, spatially homogeneous bone regeneration, significantly enhancing osteogenesis throughout
Noam Rattner, Vladimir Perlis, Eran Golden, Ariel Pokhojaev, Rachel Sarig, Itzhak Binderman, Michal Halperin‐Sternfeld, Solomon Dadia, Lihi Adler‐Abramovich   +8 more
wiley   +1 more source