Results 81 to 90 of about 2,119,107 (327)

Short-term impact of aged garlic extract on endothelial function in diabetes: A randomized, double-blind, placebo-controlled trial. [PDF]

, 2020
Impaired endothelial function portends an increased risk of cardiovascular disease. Vascular oxidative stress and systemic inflammation play a critical role in the pathogenesis and progression of vascular disease.
Birudaraju, Divya, Budoff, Matthew J, Chaganti, Bhanu T, Cherukuri, Lavanya, Flores, Ferdinand, Hamal, Sajad, Kinninger, April, Matsumoto, Suguru, Roy, Sion K, Shaikh, Kashif   +9 more
core  

Serum uric acid as a marker of microvascular damage in systemic sclerosis patients [PDF]

, 2016
Background: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction.
Amoroso, Antonio, Barbano, Biagio, Barilaro, Giuseppe, Cianci, Rosario, Di Mario, Francesca, Gasperini, Maria Ludovica, Gigante, Antonietta, Quarta, Silvia, Romaniello, Antonella, Rosato, Edoardo   +9 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Unravelling the impact of active and passive contributors to arterial stiffness in male mice and their role in vascular aging

Scientific Reports
Arterial stiffness, a key indicator of vascular health, encompassing active (vascular tone) and passive (extracellular matrix) components. This study aims to address how these different components affect arterial stiffness along the aorta and the ...
Callan D. Wesley, Cedric H. G. Neutel, Guido R. Y. De Meyer, Wim Martinet, Pieter-Jan Guns   +4 more
doaj   +1 more source

Matrix Stiffness Induces Pericyte-Fibroblast Transition Through YAP Activation

Frontiers in Pharmacology, 2021
Vascular pericytes, important mural cells that retain progenitor cell properties and protect vascular integrity in healthy tissues, are often associated with tumor development, but their functions in cancer invasion remain elusive.
Feng Feng, Feng Feng, Xueyan Feng, Xueyan Feng, Di Zhang, Di Zhang, Qilong Li, Qilong Li, Li Yao, Li Yao   +9 more
doaj   +1 more source

Mitochondrial Contributions to Vascular Endothelial Dysfunction, Arterial Stiffness and Cardiovascular Diseases.

American Journal of Physiology. Heart and Circulatory Physiology, 2021
Cardiovascular diseases (CVD) affect 1 in 3 adults and remain the leading causes of death in America. Advancing age is the major risk factor for CVD.
D. Kirkman, Austin T. Robinson, Matthew J. Rossman, D. Seals, D. Edwards   +4 more
semanticscholar   +1 more source

Impact of diabetes mellitus on ventricular structure, arterial stiffness, and pulsatile hemodynamics in heart failure with preserved ejection fraction [PDF]

, 2019
Background-Heterogeneity in the underlying processes that contribute to heart failure with preserved ejection fraction (HFpEF) is increasingly recognized.
Akers, Scott R., Bhattacharya, Priyanka, Chirinos Medina, Julio Alonso, Konda, Prasad, Kumar, Anupam, Proto, Elizabeth, Segers, Patrick, Townsend, Raymond R., Zamani, Payman   +8 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Doxorubicin induces arterial stiffness: a comprehensive in vivo and ex vivo evaluation of vascular toxicity in mice.

Toxicology Letters, 2021
Arterial stiffness is an important predictor of cardiovascular risk. Clinical studies have demonstrated that arterial stiffness increases in cancer patients treated with the chemotherapeutic doxorubicin (DOX).
M. Bosman, K. Favere, Cedric H. G. Neutel, Griet Jacobs, G. D. De Meyer, W. Martinet, E. V. Van Craenenbroeck, P. Guns   +7 more
semanticscholar   +1 more source

The acute effect of maximal exercise on central and peripheral arterial stiffness indices and hemodynamics in children and adults [PDF]

, 2016
Xavier Melo is supported by a research grant from the Foundation for Science and Technology (FCT), Ministry of Education and Science of Portugal (grant: SFRH/ BD/ 70515/ 2010). Nuno M.
Fernhall, Bo, Melo, Xavier, Pimenta, Nuno, Pinto, Rita, Santa-Clara, Helena, Santos, Diana, Sardinha, Luis   +6 more
core   +1 more source