Enhancement of doxorubicin anti-cancer activity by vascular targeting using IsoDGR/cytokine-coated nanogold [PDF]
Journal of Nanobiotechnology, 2021 Background Gold nanospheres tagged with peptides containing isoDGR (isoAsp-Gly-Arg), an αvβ3 integrin binding motif, represent efficient carriers for delivering pro-inflammatory cytokines to the tumor vasculature.
Angelo Corti +8 more
doaj +2 more sources
Vascular Endothelial Cells: Heterogeneity and Targeting Approaches
Cells, 2021 Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall passage of nutrients and diffusion of oxygen from the blood into ...
Jan K. Hennigs +3 more
doaj +2 more sources
Vascular Targeting to Increase the Efficiency of Immune Checkpoint Blockade in Cancer. [PDF]
Front Immunol, 2018 Boosting natural immunity against malignant cells has had a major breakthrough in clinical cancer therapy. This is mainly due to the successful development of immune checkpoint blocking antibodies, which release a break on cytolytic anti-tumor-directed T-
Georganaki M, van Hooren L, Dimberg A.
europepmc +2 more sources
Vascular Targeting of Radiolabeled Liposomes with Bio-Orthogonally Conjugated Ligands: Single Chain Fragments Provide Higher Specificity than Antibodies. [PDF]
Bioconjug Chem, 2018 Liposomes are a proven, versatile, and clinically viable technology platform for vascular delivery of drugs and imaging probes. Although targeted liposomes have the potential to advance these applications, complex formulations and the need for optimal ...
Hood ED +5 more
europepmc +2 more sources
Targeting vascular (endothelial) dysfunction [PDF]
British Journal of Pharmacology, 2017 AbstractCardiovascular diseases are major contributors to global deaths and disability‐adjusted life years, with hypertension a significant risk factor for all causes of death. The endothelium that lines the inner wall of the vasculature regulates essential haemostatic functions, such as vascular tone, circulation of blood cells, inflammation and ...
A. Daiber +8 more
semanticscholar +3 more sources
Tumor rim cells: From resistance to vascular targeting agents to complete tumor ablation
Tumor Biology, 2017 Current vascular targeting strategies pursue two main goals: anti-angiogenesis agents aim to halt sprouting and the formation of new blood vessels, while vascular disrupting agents along with coaguligands seek to compromise blood circulation in the ...
Khaled Seidi +2 more
doaj +2 more sources
Multimodal imaging guided preclinical trials of vascular targeting in prostate cancer. [PDF]
Oncotarget, 2015 The high mortality rate associated with castration-resistant prostate cancer (CRPC) underscores the need for improving therapeutic options for this patient population.
Kalmuk J +4 more
europepmc +2 more sources
Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm. [PDF]
ACS Nano, 2014 Targeted nanomedicine holds promise to find clinical use in many medical areas. Endothelial cells that line the luminal surface of blood vessels represent a key target for treatment of inflammation, ischemia, thrombosis, stroke, and other neurological ...
Howard M +5 more
europepmc +2 more sources
Combination of vascular surgery with novel vascular targeting agents as cancer therapeutics [PDF]
Frontiers in OncologyLocally advanced solid tumors, characterized by complex involvement or encasement of major vascular structures, present a significant challenge in curative oncology. Achieving microscopically negative margins often mandates extensive surgical procedures,
Jianxin Dong +3 more
doaj +2 more sources
Vascular targeting of nanoparticles for molecular imaging of diseased endothelium. [PDF]
Adv Drug Deliv Rev, 2017 Atukorale PU +3 more
europepmc +2 more sources