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Nature Reviews Cancer, 2005 It is now accepted that the growth of solid tumours is dependent on their capacity to acquire a blood supply, and much effort has been directed towards the development of agents (known as anti-angiogenics) that disrupt this process. More recently, it has become apparent that targeted destruction of the established tumour vasculature is another avenue ...
Neri D, Bicknell R
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Targeting tumor vascularization: promising strategies for vascular normalization
Journal of Cancer Research and Clinical Oncology, 2021Tumor recurrence after the clinical cure of tumor often results from the presence of an abnormal microenvironment, including an aberrant vasculature. The tumor microenvironment is rich in pro-angiogenic factors but lacks pro-maturation factors. Pro-angiogenic conditions in the tumor microenvironment, such as hypoxia, are double-edged swords, promoting ...
Ruiqi Zheng +3 more
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Current Oncology Reports, 2004
The role of the vascular network of a tumor has been the focus of much recent research. Angiogenesis, or the growth of new tumor blood vessels, was initially the main target in the development of novel antitumor agents. More recently, new therapeutic strategies have been designed to destroy established tumor blood vessels.
Mary Jo, Pilat +2 more
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The role of the vascular network of a tumor has been the focus of much recent research. Angiogenesis, or the growth of new tumor blood vessels, was initially the main target in the development of novel antitumor agents. More recently, new therapeutic strategies have been designed to destroy established tumor blood vessels.
Mary Jo, Pilat +2 more
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2008
Current vascular targeting strategies pursue two main goals: anti-angiogenesis agents aim to halt sprouting and the formation of new blood vessels, while vascular disrupting agents along with coaguligands seek to compromise blood circulation in the vessels.
Horsman, Michael Robert +1 more
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Current vascular targeting strategies pursue two main goals: anti-angiogenesis agents aim to halt sprouting and the formation of new blood vessels, while vascular disrupting agents along with coaguligands seek to compromise blood circulation in the vessels.
Horsman, Michael Robert +1 more
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Vascular targeting and antigen presentation
Nature Immunology, 2001The activation of macrophages, dendritic cells and other APCs depends on antigen binding to membrane surface receptors followed by internalization, intracellular processing and presentation. Several recent studies have focused on antigen targeting to APCs1, 2, 3. Two different approaches have been explored.
R, Pasqualini, D M, McDonald, W, Arap
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Inflammation-targeted vascular nanomedicine
Nature Biomedical Engineering, 2018Lipoprotein nanoparticles delivering an inflammation-targeting signalling inhibitor reduce vascular inflammation in atherosclerotic mice.
John P, Cooke, Mauro, Ferrari
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