Results 251 to 260 of about 1,860,910 (290)
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Radiobiology and vascular targeting in glioma
Current Opinion in Neurology, 2003This review examines the emerging role of agents that target tumour blood vessels in the treatment of glioma. It addresses the important issue of how these agents may best be combined with conventional radiation based therapies to optimize their effects, and reviews recent experimental and clinical data on which future treatment policies may be ...
Susan C, Short, Jackie, Harney
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Polysaccharides for Vascular Cell Targeting
Critical Reviews in Therapeutic Drug Carrier Systems, 2000Carbohydrate structures are involved in numerous biological activities such as inflammation, and cell adhesion/migration/proliferation. This gives the rationale for the design of vascular targeted drug delivery systems bearing sugar moieties. For the imaging and treatment of vascular diseases, an overview is presented with polysaccharides targeting ...
C, Blondin, I, Bataille, D, Letourneur
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Combination Vascular Targeted and Tumor Targeted Radioimmunotherapy
Cancer Biotherapy and Radiopharmaceuticals, 1999Rat MAb 201B, which binds to murine thrombomodulin, can deliver up to 50% of the injected dose of attached radioisotopes to the lung vascular endothelium. We have shown previously that intravenous injection of about 30 microCi of 213Bi-MAb 201B, which delivers about 15 Gy of alpha irradiation to the lung, is capable of eradicating small lung colonies ...
S J, Kennel +5 more
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Targeting Vascular Niche by Parathyroid Hormone
Current Medicinal Chemistry, 2008Currently, the parathyroid hormone (PTH) is a drug approved for use in humans only in bone metabolism diseases, as the osteoporosis. The PTH acts primarily by binding to its principal receptor, PTH/PTHrP-R, a member of the class B G protein-coupled receptor (GPCR) family that includes together receptors for other therapeutically important peptide ...
PAGLIARULO C +2 more
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Is Vascular Stiffness a Target for Therapy?
Cardiovascular Drugs and Therapy, 2010Early cardiovascular disease starts in the endothelium leading to functional changes in the vasculature. These changes can be depicted by assessment of arterial stiffness or elasticity. There are several techniques to assess arterial stiffness. Increased arterial stiffness or decreased arterial elasticity has been associated with cardiovascular risk ...
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Differentiation and Definition of Vascular-Targeted Therapies
Clinical Cancer Research, 2005Abstract The therapeutic potential of targeting the tumor vascular supply is now widely recognized. Intense research and development activity has resulted in a variety of investigational agents, a number of which are currently in clinical development.
Siemann, Dietmar W +7 more
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Drugs of the Future, 2006
Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
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Conventional tumor therapy typically suffers from a lack of specificity, leading to a poor therapeutic index and adverse events. The selective delivery of bioactive molecules to tumor sites represents an attractive therapeutic strategy, which promises to spare normal organs and yield medicinal agents with improved therapeutic ratios.
null Marlind, J. +2 more
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The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of..., 2007
The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary
J, Ahlskog, G, Paganelli, D, Neri
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The growth of solid tumors is dependent on their capacity to acquire blood supply. Therefore, much effort has been directed towards the development of anti-angiogenic agents which inhibit the process of neovascularization. More recently, it has become apparent that the targeted destruction of the established tumor vasculature represents a complementary
J, Ahlskog, G, Paganelli, D, Neri
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Science, 2014
Manipulating metabolism could control ...
Lee B. Rivera, Gabriele Bergers
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Manipulating metabolism could control ...
Lee B. Rivera, Gabriele Bergers
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Targeted management of vascular anomalies
Journal of the European Academy of Dermatology and VenereologyAbstract Advances in genetic sequencing technology have enabled identification of the somatic and germline variants that underlie many vascular anomalies. These pathogenic variants often affect one of two signalling pathways: (1) the PI3K (phosphoinositide 3‐kinase)/AKT (protein kinase B)/mTOR (mammalian target of
Jessie T. Lu +2 more
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