Results 261 to 270 of about 1,860,910 (290)

Targeting vascular calcification: softening-up a hard target

Current Opinion in Pharmacology, 2009
Widespread vascular calcification is a ubiquitous feature of aging and is prevalent in association with a number of common pathologies including atherosclerosis, renal failure, and diabetes. Once thought of as innocuous, emerging evidence suggests that calcification is causal in precipitating vascular events and mediating chronic cardiovascular damage,
Kapustin, Alexander, Shanahan, Catherine M.   +1 more
openaire   +3 more sources

Vascular Targets for the Treatment of Portal Hypertension

Seminars in Liver Disease, 2019
AbstractPortal hypertension is the main driver for severe complications in patients with liver cirrhosis. With improved understanding of molecular pathways that promote hepatic vascular remodeling, vasoconstriction, and sinusoidal capillarization potential vascular targets for the treatment of portal hypertension have been identified.
Ksenia, Brusilovskaya, Philipp, Königshofer, Philipp, Schwabl, Thomas, Reiberger   +3 more
openaire   +2 more sources

Drug targeting to specific vascular sites

Drug Discovery Today, 2002
The blood vessels of individual tissues are biochemically distinct, and pathological lesions put their own signature on the vasculature. In tumors, both blood and lymphatic vessels differ from normal vessels. New methods, such as in vivo screening of phage libraries, have provided peptides and antibodies that recognize these vascular signatures and can
openaire   +2 more sources

Newer Vascular Targets

2008
The identification of cell-surface markers expressed selectively by tumor vasculature is challenging. To get as close to the human disease as possible, investigators have isolated endothelial cells from fresh human tumor specimens and subjected them to RNA-based gene-expression analysis.
openaire   +1 more source

Biology and therapeutic targeting of vascular endothelial growth factor A

Nature Reviews Molecular Cell Biology, 2023
Lorena Pérez-Gutiérrez, Napoleone Ferrara   +1 more
exaly  

Vascular Targeting

2002
Renata Pasqualini, Wadih Arap
openaire   +1 more source

Vascular Access in Oncology Patients

Ca-A Cancer Journal for Clinicians, 2008
Roberto Biffi, Maurizio Gallieni, Mauro Pittiruti   +2 more
exaly  

Recent advances in angiogenesis, anti-angiogenesis and vascular targeting

Trends in Pharmacological Sciences, 2002
Roy Bicknell, Andreas Bikfalvi
exaly  

Vascular Targeting

2008
openaire   +1 more source

Targeting Apoptosis Pathways in Cancer Therapy

Ca-A Cancer Journal for Clinicians, 2005
A A Adjei
exaly