Results 21 to 30 of about 7,952,783 (243)
Targeting the Blood–Brain Tumor Barrier with Tumor Necrosis Factor-α
Pharmaceutics, 2022 The blood–brain tumor barrier represents a major obstacle for anticancer drug delivery to brain tumors. Thus, novel strategies aimed at targeting and breaching this structure are of great experimental and clinical interest.
Angelo Corti +3 more
doaj +1 more source
Targeting smooth muscle cell phenotypic switching in vascular disease
JVS: Vascular Science, 2021 Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to vessel growth and remodeling, but also contributes to cardiovascular pathologies.
Raja Chakraborty +6 more
semanticscholar +1 more source
Co-Administration of Vadimezan and Recombinant Coagulase-NGR Inhibits Growth of Melanoma Tumor in Mice [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: Tumor vascular targeting appeared as an appealing approach to fight cancer, though, the results from the clinical trials and drugs in the market were proved otherwise.
Amir Daei Farshchi Adli +5 more
doaj +1 more source
Cell Reports, 2020 Summary: Due to limited current therapies, metastases are the primary cause of mortality in cancer patients. Here, we employ a fusion compound of the cytokine LIGHT and a vascular targeting peptide (LIGHT-VTP) that homes to angiogenic blood vessels in ...
Bo He +6 more
doaj +1 more source
Pharmaceutics, 2022 Modification with polyethylene glycol (PEGylation) and the use of rigid phospholipids drastically improve the pharmacokinetics of chemotherapeutics and result in more manageable or reduced side-effects.
Mohamadreza Amin +5 more
doaj +1 more source
Frontiers in Immunology, 2023 BackgroundImmune-checkpoint inhibitors (ICIs) represent a revolution in cancer therapy and are currently implemented as standard therapy within several cancer indications.
Ane Sager Longva +2 more
doaj +1 more source
microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. [PDF]
, 2014 BackgroundmicroRNA (miRNA) are important regulators of gene expression. In patients with ischemic stroke we have previously shown that differences in immune cell gene expression are present.
Ander, Bradley P +5 more
core +5 more sources
Regional diversity in the murine cortical vascular network is revealed by synchrotron X-ray tomography and is amplified with age [PDF]
, 2018 Cortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply.
A Goring +10 more
core +5 more sources
Tumour vessel remodelling: new opportunities in cancer treatment
Vascular Biology, 2020 Tumour growth critically depends on a supportive microenvironment, including the tumour vasculature. Tumour blood vessels are structurally abnormal and functionally anergic which limits drug access and immune responses in solid cancers.
Ruth Ganss
doaj +1 more source
Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms [PDF]
, 2018 Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes.
Guzik, Tomasz J. +2 more
core +1 more source