Results 31 to 40 of about 752,279 (217)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Cell Populations Expressing Stemness-Associated Markers in Vascular Anomalies

Frontiers in Surgery, 2021
Treatment of vascular anomalies (VAs) is mostly empirical and, in many instances unsatisfactory, as the pathogeneses of these heterogeneous conditions remain largely unknown.
Ethan J. Kilmister, Lauren Hansen, Paul F. Davis, Sean R. R. Hall, Swee T. Tan, Swee T. Tan, Swee T. Tan   +6 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Stewart-treves syndrome in the lower limb after arthroplasty- A case report

Indian Dermatology Online Journal, 2022
Stewart-Treves Syndrome is a rare and fatal condition where cutaneous angiosarcoma—a high-grade malignant tumor originating in the vascular and lymphatic endothelium—classically develops in the upper limbs post-mastectomy, with radiation therapy and ...
Ishan Agrawal, Arunima Ray, Bikash R Kar, Ira Agrawal   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Giant Pyogenic Granuloma of the External Auditory Canal: A Rare Case Report

B-ENT, 2022
Pyogenic granuloma is a benign vascular tumor that usually occurs following trauma, irritation, in a background of immunosuppression or other unknown mechanisms leading to angiogenesis and vasculogenesis.
Claudio Andaloro, Rosario Corsitto, Flora Florio, Massimiliano Impalà, Giovanni Sartori, Stefano Palma, Paolo Passon, Giovanni Brondani   +7 more
doaj   +2 more sources

Cardiac dysfunction during immune checkpoint inhibitor therapy: association with extracardiac immune-related adverse events

Cardio-Oncology
Background and aims With the increasing approval of immune checkpoint inhibitors (ICI) for cancer treatment, there is a rising incidence of potentially life-threatening cancer-therapy related cardiac dysfunction (CTRCD).
Raluca I. Mincu, Lena Lampe, Lars Michel, Amir A. Mahabadi, Adelina V. Mark, Lisa Zimmer, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Tienush Rassaf, Matthias Totzeck   +10 more
doaj   +1 more source

GNA14, GNA11, and GNAQ Mutations Are Frequent in Benign but Not Malignant Cutaneous Vascular Tumors

Frontiers in Genetics, 2021
Cutaneous vascular tumors consist of a heterogeneous group of benign proliferations, including a range of hemangiomas and vascular malformations, as well as heterogeneous groups of both borderline and malignant neoplasms such as Kaposi’s sarcoma and ...
Philipp Jansen, Hansgeorg Müller, Georg C. Lodde, Anne Zaremba, Inga Möller, Antje Sucker, Annette Paschen, Stefan Esser, Jörg Schaller, Matthias Gunzer, Fabian Standl, Sebastian Bauer, Dirk Schadendorf, Thomas Mentzel, Eva Hadaschik, Klaus G. Griewank, Klaus G. Griewank   +16 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source