Results 111 to 120 of about 135,786 (259)

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Late Onset of Deep Corneal Vascularization: A Rare Complication of Intrastromal Corneal Ring Segments for Keratoconus

, 2009
Purpose To report deep corneal vascularization noted 3 years after intrastromal corneal ring segments (Intacs) implantation for the treatment of keratoconus. Methods A 33-year-old male keratoconus patient intolerant to rigid gas permeable contact lens in
M.S. Sridhar, Cemile Banu Cosar, Bozkurt Sener   +2 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Bridging the Gap: Advances and Challenges in Heart Regeneration from In Vitro to In Vivo Applications

Bioengineering
Cardiovascular diseases, particularly ischemic heart disease, area leading cause of morbidity and mortality worldwide. Myocardial infarction (MI) results in extensive cardiomyocyte loss, inflammation, extracellular matrix (ECM) degradation, fibrosis, and
Tatsuya Watanabe, Naoyuki Hatayama, Marissa Guo, Satoshi Yuhara, Toshiharu Shinoka   +4 more
doaj   +1 more source

Retinal and Choroidal Vascularization Parameters in Patients with Type 2 Diabetes Without Diabetic Retinopathy [PDF]

Artur Małyszczak,1 Joanna Wiktoria Przeździecka-Dołyk,2 Urszula Szydełko-Paśko,1 Marta Misiuk-Hojło1 1Department and Clinic of Ophthalmology, Wroclaw Medical University, Wroclaw, Dolnoslaskie, Poland ...
Małyszczak A, Przeździecka-Dołyk JW, Misiuk-Hojło M, Szydełko-Paśko U   +3 more
core  

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Paintable Decellularized‐ECM Hydrogel for Preventing Cardiac Tissue Damage

Advanced Science
The tissue‐specific heart decellularized extracellular matrix (hdECM) demonstrates a variety of therapeutic advantages, including fibrosis reduction and angiogenesis. Consequently, recent research for myocardial infarction (MI) therapy has utilized hdECM
Jaewoo Lee, Seul‐Gi Lee, Beom‐seok Kim, Shinhye Park, M. Nivedhitha Sundaram, Byung‐gee Kim, C‐Yoon Kim, Nathaniel S. Hwang   +7 more
doaj   +1 more source

Arterial vascularization of the pineal gland

, 2013
Purpose: The arterial vascularization of the pineal gland (PG) remains a debatable subject. This study aims to provide detailed information about the arterial vascularization of the PG.
Ugur, H.C., Brohi, R.A., Karahan, S.T., Özdemir, Mevci, Comert, A., Kahilogullari, G., Ozgural, O.   +6 more
core   +1 more source