Results 41 to 50 of about 108,288 (268)

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

Frontiers in Physiology, 2020
Vasculogenesis and angiogenesis are key processes of placental development, which occur throughout pregnancy. Placental vasculogenesis occurs during the first trimester of pregnancy culminating in the formation of hemangioblasts from intra-villous stem ...
Nadia Alfaidy, Nadia Alfaidy, Nadia Alfaidy, Sophie Brouillet, Gayathri Rajaraman, Bill Kalionis, Pascale Hoffmann, Pascale Hoffmann, Pascale Hoffmann, Tiphaine Barjat, Mohamed Benharouga, Padma Murthi, Padma Murthi   +12 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

A Protocol for the In Vitro Culturing of Vascularized Pancreatic Islet Organoids

Bioengineering
This study presents a protocol for co-culturing pancreatic islet cell clusters derived from pancreatic tissue with human umbilical vein endothelial cells (HUVECs) on Matrigel using a specialized culture medium to form vascularized pancreatic islet ...
Pengkun Song, Yue Wang, Junya Peng, Lei Liu, Lei Du   +4 more
doaj   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Mechanically Tunable Biofabricated Channels Enable Mimicking Arterial Pulsatility and Dynamic Tissue Actuation

Small Science
Dynamic alteration of blood vessel geometry is an inherent feature of the circulatory system. However, while the engineering of multiscale, branched, and interconnected blood vessels has been well explored, mimicking the dynamic behavior (e.g., pulsatile
Cécile Bosmans, Malin Becker, Liliana S. Moreira Teixeira, Jeroen Leijten   +3 more
doaj   +1 more source

Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes

Frontiers in Immunology
In the past two decades, several tissues have been generated from the differentiation of human pluripotent stem cells (hPSCs) to model development or disease, and for use in drug testing and cell replacement therapies.
Mohammed Usama, Mohammed Usama, Ying Deng, Ying Deng, Yiran Chen, Théa Milland, Théa Milland, Mohan Malleshaiah, Mohan Malleshaiah, Mohan Malleshaiah, Yasaman Aghazadeh, Yasaman Aghazadeh, Yasaman Aghazadeh   +12 more
doaj   +1 more source

An In Vivo Platform for Rebuilding Functional Neocortical Tissue

Bioengineering, 2023
Recent progress in cortical stem cell transplantation has demonstrated its potential to repair the brain. However, current transplant models have yet to demonstrate that the circuitry of transplant-derived neurons can encode useful function to the host ...
Alexandra Quezada, Claire Ward, Edward R. Bader, Pavlo Zolotavin, Esra Altun, Sarah Hong, Nathaniel J. Killian, Chong Xie, Renata Batista-Brito, Jean M. Hébert   +9 more
doaj   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Bioprinting‐Assisted Tissue Assembly to Investigate Endothelial Cell Contributions in Cardiac Fibrosis and Focal Fibrosis Modeling

Advanced NanoBiomed Research
Cardiac fibrosis is characterized by excessive extracellular matrix (ECM) deposition, driven by the activation of cardiac fibroblasts (cFBs) and endothelial‐to‐mesenchymal transition (EndMT). Endothelial cells (ECs) contribute to cardiac fibrosis through
Dong Gyu Hwang, Hwanyong Choi, Myungji Kim, Minji Kim, Donghwan Kim, Jinseon Park, Jinah Jang   +6 more
doaj   +1 more source