Results 61 to 70 of about 135,786 (259)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Utility of Diagnostic Ultrasound in Evaluating Fracture Healing [PDF]

Journal of Clinical and Diagnostic Research, 2014
With increase in population, modes of transportation and a fast pace of life, an individual’s chances of accident and thereby chances of getting fractured have increased significantly.
Sushil G. Kachewar, Devidas S. Kulkarni
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

In vitro vascularization of human connective microtissues

, 2007
Vascularization is one of the most central processes enabling multicellular life. Owing to the complexity of vascularization regulatory networks, minor control imbalances often have severe pathologic consequences ranging from ischemic diseases to cancer.
Doerthe Schmidt, Moritz, W, Jens M. Kelm, Martin Fussenegger, Schmidt, D, Kelm, J M, Simon P. Hoerstrup, Wolfgang Moritz, Fussenegger, M, Hoerstrup, S P   +9 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Oral fluorography: Detection of corneal vascularization [PDF]

, 1991
Corneal vascularization is a pathological process occurring in a cornea suffering physical and/or physiological insult. Its presentation could impair clear vision and thus its detection is important.
Dockter, Craig Alan, Bell, James Harvey, Cook, David Bryan   +2 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Evaluation of placental vascularization indices in monochorionic diamniotic and dichorionic diamniotic twin pregnancies [PDF]

, 2018
Objectives We aimed to investigate and compare placental vascularization indices between monochorionic-diamniotic, dichorionic- diamniotic normal twin pregnancies, and normal singular pregnancies.
Gábor Németh, Nyári Tibor András, Andrea Surányi, Gyurkovits Zita, Ábel Tamás Altorjay, Németh Gábor László, Altorjay Ábel Tamás, Surányi Andrea, Altorjay, Ábel Tamás, Surányi, Andrea, Nyári, Tibor, Tibor Nyári, Gyurkovits, Zita, Zita Gyurkovits, Németh, Gábor   +14 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source