Results 51 to 60 of about 126,160 (310)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Vascularization

, 2017
Investigating the innate organs and tissues reveals existence of abundant capillaries supporting the tissue with providing oxygen and nutrients, and withdrawing waste materials.
Yazdimamaghani, Mostafa, Tayebi, Lobat, Jose Gonzalez, Lobat Tayebi, Mostafa Yazdimamaghani, Gonzalez, Jose   +5 more
core   +1 more source

Mscs Apoptotic Vesicles Attenuated Endothelial Cell Ferroptosis For Angiogenesis

International Dental Journal
Aim or purpose: Investigating adipose-derived stem cell apoptotic vesicles (ASCs-apoVs) as angiogenic mediators through ferroptosis inhibition for enhanced diabetic wound repair.
Jinxin Kuang, Liu Jiani, Geng Dou
doaj   +1 more source

The Emerging Role of the Prokineticins and Homeobox Genes in the Vascularization of the Placenta: Physiological and Pathological Aspects

Frontiers in Physiology, 2020
Vasculogenesis and angiogenesis are key processes of placental development, which occur throughout pregnancy. Placental vasculogenesis occurs during the first trimester of pregnancy culminating in the formation of hemangioblasts from intra-villous stem ...
Nadia Alfaidy, Nadia Alfaidy, Nadia Alfaidy, Sophie Brouillet, Gayathri Rajaraman, Bill Kalionis, Pascale Hoffmann, Pascale Hoffmann, Pascale Hoffmann, Tiphaine Barjat, Mohamed Benharouga, Padma Murthi, Padma Murthi   +12 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

A Protocol for the In Vitro Culturing of Vascularized Pancreatic Islet Organoids

Bioengineering
This study presents a protocol for co-culturing pancreatic islet cell clusters derived from pancreatic tissue with human umbilical vein endothelial cells (HUVECs) on Matrigel using a specialized culture medium to form vascularized pancreatic islet ...
Pengkun Song, Yue Wang, Junya Peng, Lei Liu, Lei Du   +4 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Mechanically Tunable Biofabricated Channels Enable Mimicking Arterial Pulsatility and Dynamic Tissue Actuation

Small Science
Dynamic alteration of blood vessel geometry is an inherent feature of the circulatory system. However, while the engineering of multiscale, branched, and interconnected blood vessels has been well explored, mimicking the dynamic behavior (e.g., pulsatile
Cécile Bosmans, Malin Becker, Liliana S. Moreira Teixeira, Jeroen Leijten   +3 more
doaj   +1 more source

Navigating challenges in human pluripotent stem cell-derived islet therapy for type 1 diabetes

Frontiers in Immunology
In the past two decades, several tissues have been generated from the differentiation of human pluripotent stem cells (hPSCs) to model development or disease, and for use in drug testing and cell replacement therapies.
Mohammed Usama, Mohammed Usama, Ying Deng, Ying Deng, Yiran Chen, Théa Milland, Théa Milland, Mohan Malleshaiah, Mohan Malleshaiah, Mohan Malleshaiah, Yasaman Aghazadeh, Yasaman Aghazadeh, Yasaman Aghazadeh   +12 more
doaj   +1 more source

An In Vivo Platform for Rebuilding Functional Neocortical Tissue

Bioengineering, 2023
Recent progress in cortical stem cell transplantation has demonstrated its potential to repair the brain. However, current transplant models have yet to demonstrate that the circuitry of transplant-derived neurons can encode useful function to the host ...
Alexandra Quezada, Claire Ward, Edward R. Bader, Pavlo Zolotavin, Esra Altun, Sarah Hong, Nathaniel J. Killian, Chong Xie, Renata Batista-Brito, Jean M. Hébert   +9 more
doaj   +1 more source