Results 81 to 90 of about 560,736 (342)

Bone growth following demineralized bone matrix implantation requires angiogenesis [PDF]

, 2016
Angiogenesis is required for endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear.
Lam, Stephanie
core  

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression [PDF]

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Abramsson, Adams, Aicher, Armulik, Arosarena, Augustin, Benedito, Bergers, Blouw, Brastianos, Cancer Genome Atlas Research Network, Carmeliet, Cathrin J. Czupalla, Cattelino, Chien, Claxton, Corada, Daneman, Daneman, Devraj, Ernesto Bockamp, Estrach, Fisher, Franco, Gerhardt, Gerhardt, Harada, Harrington, Hellström, Jadranka Macas, Jakobsson, Jenny Zinke, Kamino, Karl H. Plate, Kavi Devraj, Kotliarova, Li, Liebner, Liebner, Liebner, Liebner, Lobov, Lobov, Lucero, Machein, Mailhos, Makoto M. Taketo, Marco Reis, Marcus Fruttiger, McCarty, Min, Nicole Ziegler, Noguera-Troise, Olsson, Phng, Phng, Rosario Heck, Saharinen, Sascha Seidel, Schneider, Segarra, Siekmann, Smadja, Smolich, Sonja Thom, Stefan Liebner, Stefanie Dimmeler, Stenman, Streit, Thomas, Vleminckx, Willert, Williams, Wolburg, Yano, Yano, Yoshio-Hoshino, Zhang, Zhang, Zhou   +79 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Adverse events associated with intraocular injection of anti-VEGF(bevacizumab) in retinal vein ccclusion: a case report [PDF]

, 2015
Introduction: Antiangiogenic agents are often administered for treatment of Branch Retinal Vein Occlusion (BRVO). Among them, Bevacizumab has noticeable antiangiogenic and antiedemigenic properties and possesses great capacity to penetrate the retinal ...
ARTICO, Marco, BOTTONE, Andrea, Domenica Piraino, Carmen, Mollicone, Antonella, PACELLA, Elena, PACELLA, FERNANDA, Romana Parisiella, Francesca, TURCHETTI, PAOLO   +7 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cerebral Organoids with Integrated Endothelial Networks Emulate the Neurovascular Unit and Mitigate Core Necrosis

Advanced Science
Cerebral organoids (COs) are multicellular, self‐organized, in vitro, 3D brain‐like tissues used for developmental biology, disease modelling, and drug screening.
Josep Fumadó Navarro, Siobhan Crilly, Wai Kit Chan, Shane Browne, John O. Mason, Catalina Vallejo‐Giraldo, Abhay Pandit, Mihai Lomora   +7 more
doaj   +1 more source

A clinical report of solitary gingival overgrowth in a young female patient

Journal of Pharmacy and Bioallied Sciences, 2019
Pyogenic granuloma is a type of inflammatory hyperplasia. The term “inflammatory hyperplasia” is used to describe nodular growths of oral mucosa that histologically contain inflamed fibrous and granulation tissues. It is nonneoplastic.
Hemalatha Ramakrishnan, Anisa Noorullah, Leelarani Venugopal   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

From Bioinks to Functional Tissues and Organs: Advances, Challenges, and the Promise of 3D Bioprinting

Macromolecular Materials and Engineering
3D printing, particularly bioprinting, has emerged as a transformative technology in tissue engineering and regenerative medicine, enabling the precise layer‐by‐layer fabrication of living tissues and complex biomaterials. Bioprinting has evolved through
Muhammad Wajid Ullah, Mazhar Ul‐Islam, Adeeb Shehzad, Sehrish Manan, Salman Ul Islam, Atiya Fatima, Abdullah Khamis Al‐Saidi, Mustapha El Hariri El Nokab, Juan Quevedo Sanchez, Khaled O. Sebakhy   +9 more
doaj   +1 more source

HIGH RESOLUTION X-RAY TECHNIQUES AS NEW TOOL TO INVESTIGATE THE 3D VASCULARIZATION OF ENGINEERED-BONE TISSUE

Frontiers in Bioengineering and Biotechnology, 2015
The understanding of structure-function relationships in normal and pathologic mammalian tissues is at the basis of tissue engineering (TE) approach for the development of biological substitutes to restore or improve tissue function. In this framework it
Inna eBukreeva, Michela eFratini, Michela eFratini, Gaetano eCampi, Daniele ePelliccia, Raffaele eSpanò, Giuliana eTromba, Francesco eBrun, Francesco eBrun, Manfred eBurghammer, Manfred eBurghammer, Marco eGrilli, Ranieri eCancedda, Alessia eCedola, Maddalena eMastrogiacomo   +14 more
doaj   +1 more source