Results 101 to 110 of about 19,396 (257)

Hepatorenal syndrome: an update

São Paulo Medical Journal
Hepatorenal syndrome (HRS) is the development of renal failure in patients with chronic previous liver disease, without clinical or laboratory evidence of previous kidney disease.
Tércio Genzini, Fábio César Miranda Torricelli   +1 more
doaj   +1 more source

Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Stroke clinical trials are essential for advancing stroke care but can face challenges with recruitment, retention, clinical relevance, and translation into real‐world practice. We propose that integrating community engagement and implementation science approaches into stroke trials can help address these needs.
Lesli E. Skolarus, Devin L. Brown, Bernadette Boden‐Albala   +2 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Restrictive Versus Liberal Fluid Therapy and Perioperative Outcomes in Canine Laparoscopic Cholecystectomy: A Retrospective Study of 104 Cases

Acta Veterinaria
Laparoscopic cholecystectomy in dogs induces hemodynamic and respiratory changes due to pneumoperitoneum, thereby making fluid therapy a central element of perioperative management.
Gasparotto Jean Carlos, Mangini Luiza Tonietto, Vieira Lisiane Saremba, Ohashi Gabriel Satoru, Schiefler Otávio Henrique de Melo, Freitas Gabrielle Coelho, Floriano Beatriz Perez, Brun Maurício Veloso, Soares André Vasconcelos   +8 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Optimizing Haemodynamics in Off Pump Coronary Artery Bypass Grafting: The Impact of Prophylactic Vasopressin Administration

Pakistan Armed Forces Medical Journal
Objective: To evaluate the haemodynamic effects of prophylactic low-dose vasopressin in patients undergoing off-pump coronary artery bypass grafting (OPCAB). Study Design: Quasi-experimental study. Place and Duration of Study:  Department of Cardiac
Tanveer Ahmed Khan, Muhammad Adnan Akram, Syed Aqeel Hussain, Umer Khan, Kaleem Ahmed, Syed Jawad Rehmani   +5 more
doaj   +1 more source

Physician‐Scientist Pipeline for Pediatric Rheumatology: The Current Landscape and Future Perspectives

Arthritis Care &Research, EarlyView.
Over the past 50 years, the science of pediatric rheumatology has grown exponentially due to an expansion in the understanding of complex rheumatic conditions and a surge in novel targeted therapeutics. Physician‐scientists in the field of pediatric rheumatology have played major roles in these advancements that have improved the care of children ...
Ekemini A. Ogbu, Linda T. Hiraki, Mara L. Becker   +2 more
wiley   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source

Verified Hepatorenal Syndrome Reversal As A Robust Multi-Component Primary End Point: The CONFIRM Study Trial Design

Open Access Journal of Clinical Trials, 2019
Khurram Jamil,1 S Chris Pappas,2 Florence Wong,3 Arun J Sanyal4 1Department of Scientific Affairs, Mallinckrodt Pharmaceuticals, Bedminster, NJ, USA; 2Scientific Affairs, Orphan Therapeutics, Lebanon, NJ, USA; 3Department of Medicine, Division of ...
Jamil K, Pappas SC, Wong F, Sanyal AJ
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