Results 111 to 120 of about 53,380 (285)

Astragaloside IV alleviates hypoxic pulmonary hypertension by inhibiting RELM‐β to reduce PINK1/Parkin‐mediated mitophagy in pulmonary artery smooth muscle cells (PASMCs)

British Journal of Pharmacology, EarlyView.
Background and Purpose Hypoxic pulmonary hypertension (HPH) is a chronic disorder marked by irreversible pulmonary vascular remodelling (PVR) and pulmonary artery smooth muscle cell (PASMC) dysfunction. Astragaloside IV (AS‐IV), a natural saponin from Astragalus, shows potential in HPH management. This study explores AS‐IV's protective effect on PVR in
Rongzhen Ding, Haiping Xie, Shuliu Sang, Li Qin, Yinhui Sun, Chao Zhang, Jian Yi, Hui Liu, Jianmin Fan, Guoran Peng, BeiBei Cheng, Lan Song, Aiguo Dai   +12 more
wiley   +1 more source

Endothelin-1 and Nitric Oxide levels in exudative age-related macular degeneration

Journal of Ophthalmic & Vision Research, 2015
Purpose: To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD). Methods: In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of ...
Yuksel Totan, Cemile Koca, Mesut Erdurmuş, Uğurcan Keskin, Ramazan Yiğitoğlu   +4 more
doaj   +1 more source

Sodium channel blockers are vasodilator as well as natriuretic and diuretic agents. [PDF]

, 1985
F. J. Haddy, M. B. Pamnani, B. T. Swindall, Jenessa N. Johnston, E. J. Cragoe   +4 more
openalex   +1 more source

The effects on arterial haemoglobin oxygen saturation and on shunt of increasing cardiac output with dopamine or dobutamine during one-lung ventilation [PDF]

, 2004
Publisher's copy made available with the permission of the publisher © Australian Society of AnaesthetistsTheoretically, if the cardiac output were increased in the presence of a given intrapulmonary shunt, the arterial saturation should improve as the ...
Furman W.R., Karzai W., Karzai W., Marin J.L., Russell W.J.   +4 more
core   +2 more sources

Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review

British Journal of Pharmacology, EarlyView.
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patients. Inflammation and its resolution, which often differ between sexes, are dysregulated in chronic inflammatory ...
Chloe Landy, Miles J. De Blasio, Owen L. Woodman, Pasquale Maffia, Hong Yong Peh, Cheng Xue Qin   +5 more
wiley   +1 more source

Mihai Gheorghiade, MD-Life and Concepts [PDF]

, 2018
How do you capture an idea, shape it, and then bring it into the world? Of his many talents, this ability was a fundamental characteristic of Mihai Gheorghiade.
Butler, Javed, Chioncel, Ovidiu, Collins, Sean P., Pang, Peter S.   +3 more
core   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

ISUOG Consensus Statement on maternal hemodynamic assessment in hypertensive disorders of pregnancy and fetal growth restriction

Ultrasound in Obstetrics &Gynecology, EarlyView.
T.  Stampalija, C.  Lees, T.  Ghi, J.  Cornette, W.  Gyselaers, E.  Ferrazzi, T.  Mousa, M.  Spaanderman, B.  Thilaganathan, H.  Valensise, Collaborators, J. J. Duvekot, C. Ghossein‐Doha, C. McEniery, F. Mecacci, G. P. Novelli, B. Vasopollo, I. Wilkinson   +17 more
wiley   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

A matter arising: When should inflammatory and autoimmune rheumatic diseases be considered ‘early’?

European Journal of Clinical Investigation, EarlyView.
Timely recognition of inflammatory and autoimmune rheumatic diseases (IARDs) is important to optimize the early diagnosis with tailored interventions and possible prevention of irreversible organ damage. This narrative review provides an update by summarizing the advances in identifying the early stages of rheumatoid arthritis, systemic sclerosis and ...
Elvis Hysa, Emanuele Gotelli, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Vanessa Smith, Rosanna Campitiello, Maurizio Cutolo   +7 more
wiley   +1 more source