Results 281 to 290 of about 115,075 (345)

Vertical inhibition of p110α/AKT and N‐cadherin enhances treatment efficacy in PIK3CA‐aberrated ovarian cancer cells

Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.
PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang, Hei Ip Hong, Victor C. Y. Mak, Yuan Zhou, Yiling Lu, Guanglei Zhuang, Lydia W. T. Cheung   +6 more
wiley   +1 more source

Social isolation induces sexually aggressive behaviour in male Wistar rats. [PDF]

BMC Neurosci
Ngala ME, Hemmings SMJ, Womersley JS, Shabangu TW, Qulu-Appiah L.   +4 more
europepmc   +1 more source

Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top–Down Circuit

Advanced Science, Volume 12, Issue 13, April 3, 2025.
The anterior piriform cortex (APC) exhibits distinct neural firings and calcium transients in response to familiar and novel mice, with a more robust response to the novel one. Selectively inhibiting APC pyramidal neurons disrupt social novelty recognition without impairing basic odor discrimination.
Jingwei Zhou, Zhaoyang Yin, Zhiyun Chen, Hanyu Fu, Qun Li, Shan Li, Ying Zhang, Xianzhi Zhang, Dewei Tang, Anan Li, Dejuan Wang   +10 more
wiley   +1 more source

Acute Kidney Injury During Sepsis and Prognostic Role of Coexistent Chronic Heart Failure. [PDF]

J Clin Med
Soukup J, Pliquett RU.
europepmc   +1 more source

Multidimensional Engineering of Escherichia coli for Efficient Adipic Acid Synthesis From Cyclohexane

Advanced Science, Volume 12, Issue 14, April 10, 2025.
An engineered Escherichia coli is developed to efficiently produce adipic acid (AA) from cyclohexanol, KA oil (a mixture of cyclohexanol and cyclohexanone), or cyclohexane through a combination of enzyme screening, protein fusion, and genome editing techniques. This approach has achieved the highest recorded productivity for biological AA production to
Fei Wang, Huiqi Sun, Di Deng, Yuanqing Wu, Jing Zhao, Qian Li, Aitao Li   +6 more
wiley   +1 more source

Limosilactobacillus reuteri promotes the expression and secretion of enteroendocrine- and enterocyte-derived hormones. [PDF]

FASEB J
Di Rienzi SC, Danhof HA, Forshee MD, Roberts A, Britton RA.   +4 more
europepmc   +1 more source

Adherence and persistence with direct oral anticoagulants by dose regimen: A systematic review

British Journal of Clinical Pharmacology, Volume 91, Issue 4, Page 1096-1113, April 2025.
Introduction Direct oral anticoagulants (DOACs) are used in patients with non‐valvular atrial fibrillation (NVAF) to prevent complications such as embolic events. Poor adherence to DOACs increases the risk of these complications. This manuscript reviews the impact of once‐daily (OD) vs twice‐daily (BID) dosing regimens on adherence and persistence to ...
Raúl Quirós López, Francesc Formiga Pérez, Jan Beyer‐Westendorf   +2 more
wiley   +1 more source

Vitamin B12 (hydroxocobalamin) administration in the management of persistent vasoplegic shock. [PDF]

Saudi J Anaesth
Ikram J, Williams CL, Srinivasan A, Diz Ferre JL, Ayad S.   +4 more
europepmc   +1 more source

Effect of methylprednisolone vs hydrocortisone on 30-day mortality in critically ill adults with septic shock: an analysis of the MIMIC-IV database. [PDF]

BMC Infect Dis
Xu J, Cai H, Zheng X.
europepmc   +1 more source

Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience. [PDF]

Endocr Connect
Arshad MF, Solanki S, Dancyger-Stevens L, Karunanayaka M, Loh EW, Htoon KN, Turki M, Munir A.   +7 more
europepmc   +1 more source