Results 61 to 70 of about 25,436 (310)
British Journal of Clinical Pharmacology, EarlyView.Aims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Betty S. H. Chan +3 more
wiley +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
BMEMat, EarlyView.This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu +7 more
wiley +1 more source
Biotechnology Progress, EarlyView.Abstract Shake flasks are one of the most widely used cultivation vessels in biotechnological process development. To improve the process understanding, new technologies have been reported for online monitoring of different parameters like oxygen, pH, or biomass in the last couple of years.
Lara Strehl +4 more
wiley +1 more source
Hepatorenal Syndrome in the Emergency Department: A Case Report
International Journal of Medical Students, 2015 Background: Hepatorenal syndrome is a condition where there is functional renal failure in a background of liver disease. It is relatively common in patients with liver cirrhosis and is associated with a high mortality rate if untreated. Results: This
Win Jim Tan, Mohan Tiruchittampalam
doaj
Short- and long-term reproductive effects of prenatal and lactational growth restriction caused by maternal diabetes in male rats [PDF]
, 2011 Background: A suboptimal intrauterine environment may have a detrimental effect on gonadal development and thereby increases the risk for reproductive disorders and infertility in adult life.
Amorim, Elaine MP +6 more
core +3 more sources
SAAP‐148 Oligomerizes into a Hexamer Forming a Hydrophobic Inner Core
ChemBioChem, EarlyView.The highly cationic and hydrophobic antimicrobial peptide SAP‐148 effectively eradicates multidrug‐resistant bacteria, persistent cells, and biofilms without inducing resistance. Its efficiency is likely due to its ability to disrupt bacterial membranes as an oligomer, forming a stable alpha‐helical hexameric bundle with three parallel dimers that ...
Aden Hodzic +15 more
wiley +1 more source
A review of renal protection strategies [PDF]
, 2015 Globally, more than 10 million people are affected every year by acute kidney injury (AKI) and approximately 6% of hospital patients sustain some degree of kidney injury during their hospital event.
Meyer, E
core +1 more source
ChemBioChem, EarlyView.Crotonaldehyde‐derived DNA lesions are reported in patients after ethanol exposure, which implies that crotonaldehyde is produced after ethanol ingestion. Here, we show that proline amide, which mimics N‐terminal proline residues on human proteins, can catalyze crotonaldehyde formation from the ethanol metabolite acetaldehyde under physiologically ...
Liam A. Thomas +5 more
wiley +1 more source
Neuromodulation by Oxytocin and Vasopressin [PDF]
Neuron, 2012 Oxytocin (OT) and vasopressin (VP) are two closely related neuropeptides, widely known for their peripheral hormonal effects. Specific receptors have also been found in the brain, where their neuromodulatory actions have meanwhile been described in a large number of regions.
openaire +3 more sources
ChemBioChem, Accepted Article.Flavin‐dependent halogenases (FDHs) carry out substrate‐specific and regioselective halogenation reactions in the biosynthesis of various halogenated natural compounds. Several FDHs convert non‐native substrates in vitro. However, obtaining experimental structures of FDHs with non‐native substrates remains challenging and docking often produces ...
Simon Bork +3 more
wiley +1 more source