Results 151 to 160 of about 182,452 (358)

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Bartonella infections are rare in blood-fed Ixodes scapularis and Ixodes pacificus ticks collected from rodents in the United States

Parasites & Vectors
Background Ixodes scapularis and Ixodes pacificus are important vectors of multiple pathogens in the United States. However, their role in transmission of Bartonella spp., which are commonly reported in rodents and fleas, has been debated.
Ying Bai, Lynn M. Osikowicz, Jacoby Clark, Erik Foster, Christina Parise, Sarah Maes, Rebecca J. Eisen   +6 more
doaj   +1 more source

Sentinel surveillance systems with special focus on vector-borne diseases [PDF]

, 2017
In the past few decades, vector-borne diseases have been spreading into countries previously free of these agents. It is necessary for a surveillance method to be tailored to the biology of these agents in order to detect their incursion.
Griot, C., Racloz, V., Stärk, K.D.C.
core  

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Vector-borne diseases of man and their socio-economic impact [PDF]

, 2017
Vector-borne diseases such as malaria, lymphatic filariases, schistosomiasis, leishmaniasis, onchocerciasis, trypanosomiasis, dengue and dengue haemorrhagic fever (DHF), yellow fever and Japanese encephalitis, globally account for suffering amongst more ...
Pant, C.
core  

A look at photodynamic inactivation as a tool for pests and vector-borne diseases control

, 2022
Alessandra Ramos Lima, Lucas D. Dias, Matheus Garbuio, Natália Mayumi Inada, Vanderlei Salvador Bagnato   +4 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Contained semi-field environments for ecological studies on transgenic African malaria vectors: benefits and constraints [PDF]

New interventions are needed to reduce the burden of vector-borne diseases like malaria and dengué, which are among the most serious and prevalent infectious diseases worldwide. The release of genetically modified (GM) mosquitoes may offer an alternative
Killeen, G.F., Knols, B.G.J., Mathenge, E.M., Mukabana, W.R., Njiru, B.N.   +4 more
core  

Knowledge of Mongolian veterinarians towards canine vector-borne diseases

, 2022
Cassandra Davitt, Rebecca J. Traub, Basan Batsukh, Banzragch Battur, Martin Pfeffer, Anke Wiethoelter   +5 more
openalex   +1 more source