Results 191 to 200 of about 182,452 (358)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Effect of host movement on the prevalence of vector-borne diseases. [PDF]

J Math Biol
Gao D, Lou Y.
europepmc   +1 more source

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Harnessing carlina oxide scaffold for the management of vector-borne diseases: synthesis and structure-activity relationship. [PDF]

RSC Med Chem
Spinozzi E, Piergentili A, Ferrati M, Baldassarri C, Trebaiocchi G, Rossi P, Araniti F, Zambelli A, Cappellacci L, Zeppa L, Giangrossi M, Palmieri A, Pavela R, Maggi F, Petrelli R.   +14 more
europepmc   +1 more source

Bedbugs and Vector-Borne Diseases [PDF]

Clinical Infectious Diseases, 2014
openaire   +2 more sources

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Spatial Risk Factors of Vector-Borne Diseases in Pacific Island Countries and Territories: A Scoping Review. [PDF]

Trop Med Infect Dis
Nuñez Murillo T, Cadavid Restrepo A, Mayfield HJ, Lau CL, Sartorius B, Kiani B.   +5 more
europepmc   +1 more source

EFFECT OF COMMUNITY PARTICIPATION ON KNOWLEDGE OF SELECTED VECTOR BORNE DISEASES AMONG THE SELF HELP GROUPS [PDF]

, 2014
Neethu Maria Babu, Shashidara Y N., Manjula   +2 more
openalex   +1 more source

In Focus: Vector‐borne disease [PDF]

Pest Management Science, 2007
openaire   +2 more sources

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source